Evidence map›Paper›PMID 39953802›Full record

ArticleCNS neuroscience & therapeutics2025

Fronto-Parietal and Language Network Connectivity and Its Association With Gene Expression Profiles in Bipolar Disorder Before and After Treatment.

Leyi Zhang, Haohao Yan, Chunguo Zhang, Xiaoling Li, Jiaquan Liang, Chaohua Tang, Weibin Wu, Wen Deng, Guojun Xie, Wenbin Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Leyi ZhangDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Haohao YanDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Chunguo ZhangDepartment of Psychiatry, The Third People's Hospital of Foshan, Foshan, Guangdong, China.
Xiaoling LiDepartment of Psychiatry, The Third People's Hospital of Foshan, Foshan, Guangdong, China.
Jiaquan LiangDepartment of Psychiatry, The Third People's Hospital of Foshan, Foshan, Guangdong, China.
Chaohua TangDepartment of Psychiatry, The Third People's Hospital of Foshan, Foshan, Guangdong, China.
Weibin WuDepartment of Psychiatry, The Third People's Hospital of Foshan, Foshan, Guangdong, China.
Wen DengDepartment of Psychiatry, The Third People's Hospital of Foshan, Foshan, Guangdong, China.
Guojun XieDepartment of Psychiatry, The Third People's Hospital of Foshan, Foshan, Guangdong, China.
Wenbin GuoDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.ORCID 0000-0002-1626-2465

Funding

Foshan Science and Technology Bureau 2020001005608National Natural Science Foundation of China 82171508"The 14th Five-Year" Medical High-level Key Medical Specialty Development FSGSP145069
6 · The paper itself

Abstract

backgroundThe resting-state functional connectivity (FC) patterns of the fronto-parietal network (FPN) and language network (LN) underlying bipolar disorder (BD) are obscure. This study aimed to uncover abnormal FC patterns of FPN and LN underlying BD and their evolution following treatment.

methodsImaging data at rest state and clinical variables were acquired from 82 patients with BD (with 43 finishing the follow-up) and 88 healthy controls (HCs). Seed-based FC analysis was performed, and correlations between FCs and clinical variables were investigated with whole-brain multiple regression analyses. Furthermore, a neuroimaging-transcription spatial association analysis was conducted.

resultsAt baseline, BD patients presented elevated FPN-LN and FPN-prefrontal gyrus FCs, and hyperconnectivity between the LN and bilateral thalamus, right angular gyrus (AG), and right cerebellum. Following 3 months of treatment intervention, there were decreased FCs between the FPN and left superior temporal gyrus (STG), left superior frontal gyrus (SFG), left insula, and bilateral middle temporal gyrus (MTG) (part of LN). Neuroimaging transcription analysis discovered genes correlated with FC alterations in BD.

conclusionsAberrant FC patterns of FPN and LN might be involved in the neural pathogenetic and therapeutic mechanisms of BD. We also provided potential genetic pathways underlying these functional impairments in BD.

Indexed as

Bipolar DisorderFrontal LobeLanguageNerve NetParietal LobeAdultFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeural PathwaysTranscriptomeYoung AdultAllen Human Brain Atlasbipolar disorderfronto‐parietal networkfunctional connectivityfunctional magnetic resonance imaginglanguage network

Identifiers

PMID39953802
PMCPMC11829113

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