Evidence map›Paper›PMID 39953773›Full record

ArticleInternational journal of rheumatic diseases2025

A Bidirectional Mendelian Randomization Study of Tea-Drinking Habits and Risk of Elevated Serum Uric Acid Levels.

Weitian Yan, Xingqiang Wang, Zining Peng, Qian Deng, Mengyuan Zhu, Fanyu Meng, Weiqing Zhao, Weijian Zhou, Nian Liu, Jingjin Wu and 1 more

Abstract read
In one paragraph

Article in International journal of rheumatic diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Weitian YanDepartment of Rheumatology, The No. 1 Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, Kunming, China.ORCID https://orcid.org/0009-0008-9321-1961
Xingqiang WangDepartment of Rheumatology, The No. 1 Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, Kunming, China.ORCID https://orcid.org/0000-0002-0241-7809
Zining PengThe First School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, China.ORCID https://orcid.org/0000-0003-3081-5967
Qian DengThe First School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, China.ORCID https://orcid.org/0009-0003-1201-7176
Mengyuan ZhuThe First School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, China.
Fanyu MengThe First School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, China.ORCID https://orcid.org/0000-0003-1424-5298
Weiqing ZhaoDepartment of Rheumatology and Immunology, The First People's Hospital of Yunnan Province and the Affiliated Hospital of Kunming University of Science and Technology, Kunming, China.
Weijian ZhouDepartment of Rheumatology, The No. 1 Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, Kunming, China.
Nian LiuThe First School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, China.
Jingjin WuDepartment of Rheumatology, The No. 1 Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, Kunming, China.
Jiangyun PengDepartment of Rheumatology, The No. 1 Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, Kunming, China.ORCID https://orcid.org/0000-0003-4277-1017

Funding

Construction Project Funding of University Key Laboratories in Yunnan Provincethe Construction Project for the focal branch of National Traditional Chinese MedicineThe Construction Project of National Traditional Chinese Medicine Clinical Research BaseThe Construction Project of Yunnan Provincial Fund for Medical Research Centerthe Expert Workstation of zhangxuan in Yunnan ProvinceThe Funding of Yunnan Applied Basic Research Projects-Union FoundationThe Funding of Yunnan Provincial Health Science and Technology Plan
6 · The paper itself

Abstract

backgroundAlthough recent animal experiments have revealed that tea intake improves elevated serum uric acid (SUA) levels, a causal link between the consumption of different types of tea and SUA levels remains undetermined.

methodsBidirectional Mendelian randomization (MR) analysis based on genome-wide association studies was used to assess the causal relationship between consumption of different types of tea and the risk of elevated SUA levels in European and Asian populations.

resultsForward MR analysis showed that tea intake was significantly associated with lower SUA levels (p = 0.0013). The estimated effect value (

conclusionAlthough this bidirectional MR study provided evidence of a causal relationship between tea intake and SUA levels, however, due to limitations associated with the sample size and strength of instrumental variables, a definite conclusion was not possible.

Indexed as

Drinking BehaviorHyperuricemiaTeaUric AcidAsian PeopleBiomarkersGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMendelian Randomization AnalysisPhenotypePolymorphism, Single NucleotideRisk AssessmentRisk FactorsWhite PeopleBiomarkersTeaUric Acidbidirectional Mendelian randomizationserum uric acidtea intake

Identifiers

PMID39953773
PMCPMC11829186

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.