Trial reportJournal of clinical periodontology2025
Impact of Collagen Membrane in Vertical Ridge Augmentation Using Ti-Reinforced PTFE Mesh: A Randomised Controlled Trial.
Trial report in Journal of clinical periodontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04843488 (Effectiveness of Different Membrane Applications), which is not on this map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of Different Membrane Applications (Perforated Polytetrafluroethylene (PTFE) vs. Perforated PTFE+ Collagen Membrane) in Vertical Ridge Augmentation - Randomized Clinical Trial
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Efficacy of engineered scaffolds for horizontal and vertical ridge augmentation: A systematic review and meta-analysis.Journal of periodontology · 2026Pooled it
- Resorbable scaffolds for alveolar ridge augmentation procedures: A systematic review.International journal of implant dentistry · 2026Pooled it
- Effect of Membrane Perforations With and Without Collagen Membrane Coverage in Vertical Ridge Augmentation: An Experimental Pilot In Vivo Study.Clinical oral implants research · 2026Article
- H-PRF Bone Block Versus Sausage Technique for Horizontal Ridge Augmentation: A Retrospective Study.Clinical implant dentistry and related research · 2026Article
- Guided Bone Regeneration for Vertical Alveolar Augmentation: Clinical Evaluation of d-PTFE-Ti Membranes and Comparison with Collagen Membranes: A Systematic Review.Journal of functional biomaterials · 2026Review
- Effect of pseudo-periosteum on hard and soft tissue regeneration following lateral bone augmentation using a titanium mesh: an experimentalJournal of periodontal & implant science · 2026Article
- Vertical and Horizontal Ridge Augmentation with Titanium-Reinforced Dense PTFE and Reinforced PTFE Mesh: A Prospective Comparative Case Series.Journal of functional biomaterials · 2026Article
- Immediate vs. Delayed Implant Placement Following Alveolar Ridge Procedures with Xeno-Hybrid Bovine Bone Graft: A Retrospective Cohort with Operator-Level Comparison.Diagnostics (Basel, Switzerland) · 2026Article
- The Regenerative Effect of Various Barrier Membranes With and Without Bone Grafting in Critical Size Defects in Rabbit Calvaria.Clinical and experimental dental research · 2026Article
- Recent Advances in Regenerative Therapies in Periodontology.Dentistry journal · 2025Review
- In Vitro Evaluation and Comparative Analysis of Resorbable Membranes for Guided Bone Regeneration.Medicina (Kaunas, Lithuania) · 2025Article
- Customized 3D-Printed Scaffolds for Alveolar Ridge Augmentation: A Scoping Review of Workflows, Technology, and Materials.Medicina (Kaunas, Lithuania) · 2025Article
- Accompanying Titanium Meshes and Titanium-Reinforced Membranes with Collagen Membranes in Vertical Alveolar Ridge Augmentations: A Systematic Review.Journal of functional biomaterials · 2025Review
- Clinical Evaluation of a Magnesium-based Barrier Membrane for Guided Bone Regeneration.In vivo (Athens, Greece)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThis non-inferiority randomised clinical trial aimed to compare vertical bone gain (VBG), volumetric bone changes and incidence of complications after vertical ridge augmentation (VRA) using perforated titanium-reinforced dense-polytetrafluoroethylene (PTFE) mesh covered by a collagen membrane (CM) or used alone. MATERIALS AND
methodsThirty patients with vertical bone defects were randomly assigned to receive VRA with either PTFE + CM or PTFE alone. Meshes were removed after 9 months. Clinical assessments included complication rates, pseudo-periosteum type and bone density. VBG, effective regeneration rate and the need for additional augmentation were evaluated using CBCT reconstructions.
resultsNon-inferiority of PTFE alone compared with PTFE + CM was not demonstrated for absolute and relative VBG (4.5 ± 2.1 mm vs. 4.1 ± 2.7 mm, 79.2% ± 16.6% vs. 85.8% ± 10.6%, respectively), effective regeneration rates (69.3% ± 17.9% vs. 72.3% ± 16.4%, respectively) or complication rates (6.7% in both groups). A higher incidence of type 1 pseudo-periosteum was observed in the PTFE + CM group.
conclusionThe non-inferiority of PTFE alone compared with PTFE + CM for absolute VBG was not established. However, both techniques led to comparable outcomes for VBG, complication rates and bone density. The higher incidence of type 1 pseudo-periosteum and lacking bone volume in the PTFE + CM group suggests that adding a collagen membrane may help prevent soft tissue ingrowth.
trial registrationClinicaltrials.gov identification number: NCT04843488.
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