ArticleJournal of animal science2025
Investigation of the nutritional and functional roles of a microencapsulated blend of botanicals on intestinal health and growth of nursery pigs challenged with F18+Escherichia coli.
Article in Journal of animal science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Research summary: influence of immune and oxidative stress biomarkers ins the jejunal mucosa on growth performance of nursery pigs.Animal frontiers : the review magazine of animal agriculture · 2026Article
- Strategically isolated bacteriophages targeting ETEC K88 (F4) alleviate post-weaning diarrhea in piglets via modulation of gut microbiota and inflammatory responses.Journal of animal science and biotechnology · 2026Article
- Provision of porcine milk oligosaccharides to support the weaning transition in nursery pigs fed diets including bovine milk co-products.Journal of animal science · 2026Article
- Nutritional needs of non-essential amino acids for intestinal health and growth performance of nursery pigs fed diets without soybean meal.Journal of animal science · 2026Article
- Antibiotics and Opportunities of Their Alternatives in Pig Production: Mechanisms Through Modulating Intestinal Microbiota on Intestinal Health and Growth.Antibiotics (Basel, Switzerland) · 2025Review
- Efficacy of an herb and essential oil-based phytobiotic blend and its interaction with an antibiotic on intestinal health, growth performance, and carcass characteristics in growing pigs.Journal of animal science · 2025Article
- Effect of a trub, hops, and yeast mixture on jejunal mucosal immune status, oxidative stress status, structure, and growth performance of nursery pigs.Journal of animal science · 2025Article
- Potential of fermented herbal extracts to modulate digestion and gut microbiota during the weaner and fattening period on commercial pig farms.Frontiers in veterinary science · 2025Article
- The Weaning of Pigs: Mechanistic Outcomes to Intestinal Immunity and Integrity.Animal science journal = Nihon chikusan GakkaihoReview
- Effects of Dietary Marine Sulfated Polysaccharides Derived From Macroalgae on Intestinal Health of Nursery Pigs.Animal science journal = Nihon chikusan GakkaihoArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The study aimed to evaluate the effects of increasing levels of a microencapsulated blend of botanicals (MBB) on the intestinal health and growth performance of nursery pigs challenged with F18+E. coli. Sixty-four nursery pigs (6.8 ± 0.3 kg) were assigned to 4 dietary treatments in a randomized complete block design, with initial body weight and sex as blocks, and fed for 28 d in 3 phases. Treatments were a basal diet fed to pigs without F18+E. coli challenge (NC) and 3 levels of MBB (0.0%, 0.1%, and 0.2%) in pigs challenged with F18+E. coli. On day 7 of the study, pigs in the challenged group were orally inoculated with F18+E. coli (1.5 × 1010 CFU). On days 7 and 21 post-challenge, pigs were euthanized to collect jejunal tissues and mucosa. Compared to the NC, 0.0% MBB increased (P < 0.05) relative abundance (RA) of Staphylococcus saprophyticus and reduced (P < 0.05) Streptococcus parasuis at days 7 and 21 post-challenge, respectively. Increasing levels of MBB decreased (linear: P < 0.05) RA of S. saprophyticus on day 7 post-challenge. Compared to the NC, 0.0% MBB increased (P < 0.05) jejunal NOD2 and IL-6 expression and decreased (P < 0.05) ZO-1 on day 7 post-challenge. Compared to the NC, 0.0% MBB decreased (P < 0.05) jejunal IL-6, IL-8, and TNF-α and increased (P < 0.05) IgG on day 21 post-challenge. Increasing levels of MBB increased OCLN (linear: P < 0.05) and ZO-1 (linear and quadratic: P < 0.05) on day 7 post-challenge and decreased toll-like receptor 4 (TLR4; linear and quadratic: P < 0.05). Compared to the NC, 0.0% MBB decreased (P < 0.05) Ki-67+ on day 7 post-challenge. Increasing levels of MBB increased (linear: P < 0.05) Ki-67+ on day 7 post-challenge and villus height (VH):CD on d 21 post-challenge. In the overall period, compared to the NC, 0.0% MBB decreased (P < 0.05) average daily gain. Increasing daily MBB intake linearly increased OCLN on day 7 and VH:CD on day 21, and reduced TLR4 and IL-8 on day 21 post-challenge, but exhibiting quadratic effects (P < 0.05) on ZO-1 (optimal at 0.12% of MBB), IgG (optimal at 0.14% of MBB), and G:F during days 7 to 20 and days 7 to 28 (optimal at 0.22% and 0.10% of MBB, respectively). In conclusion, F18+E. coli challenge negatively modulated the jejunal mucosal microbiota and reduced intestinal morphology and growth of nursery pigs. Supplementation of MBB at 0.10% to 0.14% provided optimal mitigation of the impacts of F18+E. coli challenge on humoral immunity, intestinal integrity, jejunal morphology, and feed efficiency of pigs.
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