SynthesisCritical care (London, England)2025
Early high-sensitivity troponin elevation and short-term mortality in sepsis: a systematic review with meta-analysis.
Synthesis in Critical care (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Community-acquired pneumonia withJournal of thoracic disease · 2026Article
- Equiflow: An open-source software package for evaluating changes in cohort composition.PLOS digital health · 2026Article
- Myocardial Injury During the Immediate Postoperative Period After Endovascular Aortic Repair: A Prospective Observational Study.Bioengineering (Basel, Switzerland) · 2026Article
- Development and validation of a clinical prediction model for sepsis-induced cardiomyopathy.Frontiers in cardiovascular medicine · 2026Article
- Immune Biomarker Profiling Across Clinical States and Development of a SOFA-Integrated Model for 28-Day Mortality Prediction in Sepsis: A Prospective Cohort Study.Infection and drug resistance · 2026Article
- A Machine Learning-Based Prognostic Model for Sepsis-Associated Liver Injury Using Routine Indicators.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2026Article
- Cardiac Troponin I as a Prognostic Indicator of Mortality in Patients With Sepsis and Organ Dysfunction.Cureus · 2026Article
- Integrated single-cell and bulk transcriptomic analyses reveal cDC1-centered ubiquitination dysregulation and identify UBE2F as a critical regulator in sepsis.Frontiers in immunology · 2026Article
- Association of Long-Term Oral β-Blocker Use With Cardiac Troponin I and B-Type Natriuretic Peptide in Septic Myocardial Injury: A Retrospective Cohort Study.Health science reports · 2025Article
- Early lactate dynamics for short-term mortality in emergency department sepsis.BMC emergency medicine · 2025Observational
- Revisiting High-Sensitivity Cardiac Troponin Abnormal Baseline Cutoffs: Implications for AMI Diagnosis in the Emergency Department.Journal of clinical medicine · 2025Article
- From Fluid Responsiveness to Prognosis: The Emerging Role of Point-of-Care Echocardiography in Sepsis.Diagnostics (Basel, Switzerland) · 2025Review
- Laboratory and Microbiological Considerations in Sepsis-Induced Cardiac Dysfunction.Medicina (Kaunas, Lithuania) · 2025Article
- Inflammatory Profile and Risk of Post-Intervention Infection in Relation to Myocardial Necrosis Markers.Healthcare (Basel, Switzerland) · 2025Article
- Correlation Between Cardiac Troponin Serum Concentration and Selected Parameters of Subclinical Cardiovascular Dysfunction in Patients With and Without Arterial Hypertension: Retrospective Cross-Sectional Analysis of Real-World Data.Journal of clinical medicine · 2025Article
- Review
- The sicker the patient, the higher the mortality.Critical care (London, England) · 2025Article
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7 authors.
Funding
Abstract
backgroundSerum cardiac troponin (cTn) elevation is a well-established phenomenon in sepsis. However, the clinical significance of this phenomenon with high-sensitivity (hs) assays and the current sepsis definition needs to be settled. RESEARCH QUESTION: What is the association between early serum cTn levels measured by hs-assays and the risk of short-term mortality in septic patients? STUDY DESIGN AND
methodsWe conducted a systematic review using a comprehensive PubMed, Scopus, and Embase search. Studies were eligible if they reported association data on early hs-cTn and mortality in an adult sample with sepsis that met the Sepsis-3 definition. For the synthesis of the effect of hs-cTn on mortality, we applied random effect models on the pooled unadjusted and adjusted odds ratio (OR and aOR, respectively) of elevated vs. normal hs-cTn serum values, and on the crude standardized mean difference (SMD) of hs-cTn between survivors and non-survivors.
resultsIn total, 6242 patients from 17 studies were included, with short-term mortality rates ranging from 16.9% to 53.8%. Using a crude analysis, non-survivor patients showed higher hs-cTn than survivors (SMD of 0.87, 95%CI: 0.41-1.33). Elevated hs-cTn was associated with increased mortality (OR = 1.78, 95% CI: 1.41-2.25). However, this prognostic effect was absent in studies that adjusted for different confounders (aOR = 1.06, 95% CI: 0.99-1.14). DISCUSSION AND
conclusionsNon-survivors of sepsis exhibited significantly elevated hs-cTn levels. While elevated hs-cTn levels are associated with an increased risk of mortality, they are not independently associated with this outcome in sepsis.
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