ArticleParasites & vectors2025
Impact of the intensity of infection in birds on Plasmodium development within Culex pipiens mosquitoes.
Article in Parasites & vectors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundIn vector-borne diseases, invertebrate hosts are exposed to highly variable quantities of parasites during their blood meal. This heterogeneity may partly explain the overdispersed distribution of parasites within the vector population and the variability in the extrinsic incubation period (EIP) of the parasite. Indeed, the quantity of parasites ingested is often considered as a good predictor of the quantity of parasites that will develop within the vectors, as well as the speed at which they will develop (i.e. EIP). However, density-dependent processes can influence the relationship between parasite burden in the vertebrate host and in vectors, making this relationship unclear at times.
methodsHere, we used an avian malaria system to investigate whether the proportion of red blood cells infected by sexual and/or asexual stages of Plasmodium relictum influences the intensity of infection and the EIP within vectors. For this purpose, we experimentally infected 12 birds in order to generate a range of infection intensity. More than 1000 mosquitoes took a blood meal on these hosts, and the development of Plasmodium within the vectors was followed for more than 20 days.
resultsOur study reveals a negative relationship between the intensity of infection in birds and the time until 10% of mosquitoes become infectious (EIP
conclusionsWhile the quantity of ingested parasites had no impact on oocyst and sporozoite burden in infectious mosquitoes, the EIP
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