ArticleLipids in health and disease2025
Association of triglyceride-glucose index and derived indices with cataract in middle-aged and elderly Americans: NHANES 2005-2008.
Article in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Triglyceride-Glucose-Related Indexes as Risk Factors for Vision-Threatening Ocular Diseases: A Prospective UK Biobank Study.Investigative ophthalmology & visual science · 2026Article
- Association of frailty index with sarcopenia: Mediation analysis of triglyceride-glucose-related indices: a cross-sectional study.Medicine · 2026Article
- Active-fluidics versus gravity-fluidics system in phacoemulsification for type 2 diabetes mellitus without diabetic retinopathy: a retrospective observational study.BMC ophthalmology · 2026Observational
- Causal effect of obesity on cataract and mediating roles of metabolites: a Mendelian randomization study.International journal of ophthalmology · 2026Article
- Association between inflammatory biomarkers and cataracts: validation from the NHANES database and clinical studies.Frontiers in nutrition · 2026Article
- Development and validation of age- and gender-specific reference intervals for the triglyceride-glucose index in a large Chinese healthy adult population.Frontiers in endocrinology · 2026Article
- The Association Between Sleep Health and a History of Cataract Surgery in the United States Based on the National Health and Nutrition Examination Survey (NHANES) 2005-2008.Healthcare (Basel, Switzerland) · 2025Article
- Article
- Association between red blood cell distribution width to albumin ratio (RAR) and cataract risk: A cross-sectional study from NHANES 1999-2008.Advances in ophthalmology practice and researchArticle
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Abstract
aimExplore the relationship between the triglyceride-glucose (TyG) index, along with its derivative indices, and the prevalence of cataracts.
methodsData from 20,497 participants in the 2005-2008 National Health and Nutrition Examination Survey (NHANES) were compiled. A final total of 4,499 individuals met the eligibility criteria. Cataract presence was assessed through a self-reported history of cataract surgery. The TyG index and its derivatives-TyG-waist-to-height ratio (WHtR), TyG-neutrophil-to-lymphocyte ratio (NLR), TyG-monocyte-to-lymphocyte ratio (MLR), TyG-log platelet-to-lymphocyte ratio (lgPLR), TyG-log systemic inflammation index (lgSII), and TyG-systemic inflammation response index (SIRI)-were calculated. Statistical analyses included multivariable logistic regression, restricted cubic spline (RCS) curves for nonlinear relationships, and receiver operating characteristic (ROC) analysis.
resultsHigher TyG indices were significantly associated with cataract presence (P < 0.001). Specifically, TyG-WHtR, TyG-NLR, TyG-lgPLR, TyG-lgSII, and TyG-SIRI exhibited positive correlations with cataract prevalence, even after adjustment for potential confounders (odds ratio [OR] = 1.17; 95% confidence interval [CI]: 1.01, 1.37; P = 0.0403; [OR] = 1.01; 95% [CI]: 1.00, 1.02; P = 0.0258; [OR] = 1.08; 95% [CI]: 1.01, 1.16; P = 0.0223; [OR] = 1.08; 95% [CI]: 1.03, 1.14; P = 0.001; [OR] = 1.02; 95% [CI]: 1.00, 1.04; P = 0.0120). Furthermore, the stratified analysis showed that in the 61-85 age group, TyG-lgPLR and TyG-lgSII remained positively associated with cataract prevalence ([OR] = 1.09; 95% [CI]: 1.01, 1.17; P = 0.024; [OR] = 1.08; 95% [CI]: 1.02, 1.13; P = 0.005). RCS analysis revealed a linear association between these indices and cataracts, with no apparent threshold effect. ROC analysis indicated that TyG-MLR demonstrated the highest predictive ability for cataract presence.
conclusionThe study results indicate a positive association between TyG-related indicators and cataract the prevalence of cataracts in middle-aged and elderly individuals, suggesting that these markers may serve as practical biomarkers for identifying high-risk individuals. Early detection and management of metabolic and inflammatory factors could contribute to effective preventive strategies for cataract development in the elderly population.
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