ArticleBMC public health2025
Exploring the association between exposure to pesticides, polycyclic aromatic hydrocarbons, and phthalates and metabolic syndrome in National Health and Nutrition Examination Survey in the USA, 2007-2012: utilizing a multi-step statistical strategy.
Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Microplastics, Endocrine Disruptors, and Oxidative Stress: Mechanisms and Health Implications.International journal of molecular sciences · 2025Review
- Ovotoxicant VCD disrupts oocyte meiosis in mice by impairing m6A/IGF2BP3-mediated mRNA stability.Communications biology · 2025Article
- Association between organophosphate insecticide metabolites and lung function in U.S. adults: NHANES 2011-2012.Therapeutic advances in respiratory diseaseArticle
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Authors and funding
6 authors.
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Abstract
backgroundPesticides, polycyclic aromatic hydrocarbons (PAHs), and phthalates are recognized as potential contributors to metabolic disorders. Nevertheless, the combined effect of simultaneous exposure to these chemicals on the metabolic syndrome (MetS) remains elusive.
objectivesTo explore the impacts of simultaneous exposure to pesticides, PAHs and phthalates and identify critical chemicals on MetS.
methodsBased on the National Health and Nutrition Examination Survey (NHANES) database from 2007-2012, our study included 4030 non-pregnant individuals aged 20 years or older. We used the weighted linear regression model, variable selection models (including LASSO regression and BMA models), as well as a mixture exposure model (WQS model) to investigate the correlation between chemicals and MetS. Additionally, stratified analyses were performed based on gender and age.
resultsThe weighted generalized linear regression model revealed a positive correlation of 2-hydroxyphenanthrene (2-PHEN) with MetS (OR: 1.37, 95% CI: 1.19-1.59, P < 0.001). Both the LASSO regression and BMA models identified 2-PHEN as a significant chemical positively associated with MetS. Additionally, the WQS model showed a positive association between overall exposure to the three chemical categories and MetS, with the highest weighted chemicals being 2-PHEN. Stratified analyses demonstrated a significant correlation between 2-PHEN and MetS between different subgroups. Notably, the WQS regression model revealed a significant association in the subgroup of female (OR = 1.40, 95% CI: 1.08-1.83, P < 0.05), with 2-PHEN, 2,5-dichlorophenol (2,5-DCP), 2-hydroxynaphthalene (2-NAP), and mono-ethyl phthalate (MEP) identified as the primary contributions to MetS.
conclusionCombined exposure to the three chemical groups was associated with an increased risk of MetS, with the PAHs group exhibiting the most pronounced effect and 2-PHEN emerging as a key chemical, underscoring significant public health concerns regarding the potential health risks of endocrine-disrupting chemicals (EDCs) exposure to metabolic diseases.
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