Evidence map›Paper›PMID 39953433›Full record

SynthesisBMC public health2025

A systematic review exploring the role of tuberculosis stigma on test and treatment uptake for tuberculosis infection.

Ayşenur Kılıç, Xuanyu Zhou, Zoe Moon, Yohhei Hamada, Trinh Duong, Charlotte Layton, Sobhash Jhuree, Ibrahim Abubakar, Molebogeng X Rangaka, Robert Horne

Abstract readSystematic Review
In one paragraph

Synthesis in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ayşenur KılıçSchool of Pharmacy, University College London, London, WC1H 9JP, UK.
Xuanyu ZhouSchool of Pharmacy, University College London, London, WC1H 9JP, UK.
Zoe MoonSchool of Pharmacy, University College London, London, WC1H 9JP, UK.
Yohhei HamadaInstitute for Global Health, University College London, London, UK.
Trinh DuongMRC Clinical Trials Unit, University College London, London, UK.
Charlotte LaytonMRC Clinical Trials Unit, University College London, London, UK.
Sobhash JhureeNOCLOR NHS Research Office, London, UK.
Ibrahim Abubakar *Institute for Global Health, University College London, London, UK.
Molebogeng X Rangaka *Institute for Global Health, University College London, London, UK.
Robert Horne *School of Pharmacy, University College London, London, WC1H 9JP, UK. r.horne@ucl.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTuberculosis (TB) stigma may be a barrier to engagement in testing and treatment for TB infection (TBI). We systematically reviewed the available evidence on how TB stigma influences engagement with TBI testing and treatment.

methodsElectronic databases (e.g., CINAHL, Central, OVID) were searched from 1963 to 1st August 2024. Quantitative, qualitative, and mixed-method studies reporting the effects of TB stigma on engagement with TBI testing and treatment were included in the review. Descriptive synthesis was applied to the quantitative studies, and thematic analysis was applied to qualitative studies. The risk of bias was assessed by using the mixed methods appraisal tool.

resultsSeventeen studies were included in the review (12 qualitative, four quantitative and one mixed methods). TB stigma was complex and multifactorial with six overlapping domains: public, anticipated, self, experienced, secondary, and structural. Perceptions or experiences of stigma were associated with lower rates of engagement in testing and adherence to treatment in TBI.

conclusionsPerceptions of TB stigma among people with TBI were related to the common social representation of TB disease such as its being contagious or disease of the poor. Negative perceptions of active TB appear to carry over to its infection, despite people being informed about the nature of TBI. Our findings could inform more effective communication to support TBI testing and treatment engagement.

Indexed as

Patient Acceptance of Health CareSocial StigmaTuberculosisHumansAdherenceInfectionPreventionTBTest and treatTuberculosis

Identifiers

PMID39953433
PMCPMC11829483

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.