ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2025
Streptococcus pneumoniae keratitis: epidemiology and outcomes over 6 years in a French eye care center.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Rapid Pathogen Detection in Severe Infectious Keratitis: Prospective Evaluation of Combined Multiplex PCR Panels Versus Standard Microbiology.Ophthalmology and therapy · 2026Article
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7 authors.
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Abstract
purposeWe evaluated the epidemiology, clinical features, microbiology, management and visual outcome of Streptococcus pneumoniae keratitis.
methodsWe retrospectively reviewed the medical charts of patients diagnosed with culture-proven Streptococcus pneumoniae keratitis in a French tertiary center between January 2015 and December 2020.
resultsWe analyzed data from 51 eyes of 51 patients with Streptococcus pneumoniae keratitis followed for 64 (19-105) days, out of a total of 1222 eyes with documented bacterial keratitis (4.17%). Most cases (55%) occurred in winter or spring (p = 0.037). A local or systemic risk factor was identified in 39 (76%) and 32 (63%) eyes respectively: previous ocular surgery (55%) followed by glaucoma (24%), and diabetes (18%). Forty-one patients (80%) with severe keratitis remained in hospital for 7 (1-60) days. Polymicrobial infection was detected in 6 eyes (12%) and multidrug resistant strain in 9 eyes (18%). Medical treatment lasted 36 (21-60) days. Adjuvant surgery was required in 13 eyes (25%) mainly for delayed ulcer healing (n = 10), with amniotic membrane transplantation (n = 12) or tectonic keratoplasty (n = 1). In multivariate analysis, endothelial plaque (OR 65.87, p = 0.028), hypopyon (OR 17.8, p = 0.040), and infiltrate > 5mm
conclusionStreptococcus pneumoniae keratitis are rare in France but may be sight-threatening. Overall VA is poor, most of patients require hospitalization, and some local factors at presentation predict the need for adjuvant surgery.
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