Evidence map›Paper›PMID 39953365›Full record

ArticleCurrent microbiology2025

The Two-Component System TtrRS Regulates the Expression of the 05890-05900 Operon that Promotes the Sulfur Metabolism of Vibrio parahaemolyticus.

Yameng Bai, Tianqi Liang, Jie Zhao, Yawen Lin, Qian Lu, Xiujuan Zhou, Menghua Yang, Xiaojun Zhong

Abstract read
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Article in Current microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yameng Bai *College of Animal Science and Technology, College of Veterinary Medicine, Zhejiang A & F University, Key Laboratory of Applied Technology On Green-Eco-Healthy Animal Husbandry of Zhejiang Province, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, Hangzhou, China.
Tianqi Liang *College of Animal Science and Technology, College of Veterinary Medicine, Zhejiang A & F University, Key Laboratory of Applied Technology On Green-Eco-Healthy Animal Husbandry of Zhejiang Province, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, Hangzhou, China.
Jie ZhaoNanjing Dr. Vet Health Management Co., Ltd, Nanjing, China.
Yawen LinCollege of Animal Science and Technology, College of Veterinary Medicine, Zhejiang A & F University, Key Laboratory of Applied Technology On Green-Eco-Healthy Animal Husbandry of Zhejiang Province, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, Hangzhou, China.
Qian LuCollege of Animal Science and Technology, College of Veterinary Medicine, Zhejiang A & F University, Key Laboratory of Applied Technology On Green-Eco-Healthy Animal Husbandry of Zhejiang Province, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, Hangzhou, China.
Xiujuan ZhouCollege of Animal Science and Technology, College of Veterinary Medicine, Zhejiang A & F University, Key Laboratory of Applied Technology On Green-Eco-Healthy Animal Husbandry of Zhejiang Province, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, Hangzhou, China.
Menghua YangCollege of Animal Science and Technology, College of Veterinary Medicine, Zhejiang A & F University, Key Laboratory of Applied Technology On Green-Eco-Healthy Animal Husbandry of Zhejiang Province, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, Hangzhou, China. yangmh@zafu.edu.cn.
Xiaojun ZhongCollege of Animal Science and Technology, College of Veterinary Medicine, Zhejiang A & F University, Key Laboratory of Applied Technology On Green-Eco-Healthy Animal Husbandry of Zhejiang Province, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, Hangzhou, China. xjzhong@zafu.edu.cn.

Funding

National Natural Science Foundation of China 32170174National Natural Science Foundation of China 32202804Science Development Foundation of Zhejiang A & F University 2013FR012Talent-Start project of Zhejiang A & F University 2020FR042Zhejiang Provincial Natural Science Foundation of China LQ22C180002
6 · The paper itself

Abstract

The marine bacterium Vibrio parahaemolyticus is responsible for the seafood-borne gastroenteritis in humans. Two-component system (TCS) TtrRS plays important roles in host colonization and works as an important regulator in V. parahaemolyticus. However, the mechanisms by which TtrRS regulates the downstream genes, as well as the function of their target genes, remain largely unknown. In this study, we performed a Find Individual Motif Occurrences (FIMO) analysis using the ttrR box to scan the V. parahaemolyticus genome and identified 68 potential binding sites harboring the ttrR box. Thereinto, a ttrR box exists in the promoter region of the 05890-05900 operon. We further demonstrated that TtrR directly regulates the expression of the 05890-05900 operon by binding to the ttrR box. In addition, another TCS, 05905/05910, could assist in the regulation of TtrR to the 05890-05900 operon. Subsequent study showed that the 05890-05900 operon promotes the sulfur metabolism of V. parahaemolyticus at the early growth stage. Our results suggested that TtrRS and their target genes generate a complex regulatory pathway to better control sulfur metabolism in V. parahaemolyticus.Please check and confirm the edit made in the article title and amend if necessary.It's OK.

Indexed as

Bacterial ProteinsGene Expression Regulation, BacterialOperonSulfurVibrio parahaemolyticusPromoter Regions, GeneticBacterial ProteinsSulfur

Identifiers

PMID39953365

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.