ArticleAnnals of surgical oncology2025
Conversion from Radical Esophagectomy to Definitive Chemoradiotherapy After Neoadjuvant Chemotherapy for Advanced Esophageal Squamous Cell Carcinoma: Treatment Options Based on Chemotherapy Response.
Article in Annals of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Article
- Conversion Therapy for cT4b and M1 Esophageal Squamous Cell Carcinoma: A Comprehensive Systematic Review.Annals of gastroenterological surgery · 2026Review
- Small bowel metastasis during organ preservation in patients with esophageal squamous cell carcinoma: case report and literature review.Frontiers in oncology · 2025Article
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Authors and funding
10 authors.
Funding
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Abstract
backgroundRadical esophagectomy after neoadjuvant chemotherapy (NAC) is the established strategy for resectable advanced esophageal cancer. However, some patients are converted to definitive chemoradiotherapy (dCRT) after NAC due to reasons such as their wishes or disease progression, and their prognosis remains uncertain. This study aimed to investigate the prognosis of patients who converted to dCRT.
methodsPatients who underwent NAC for resectable advanced esophageal squamous cell carcinoma between 2006 and 2020 were enrolled in this study retrospectively. The prognostic impact of subsequent treatment after NAC, planned surgery, or conversion to dCRT, was compared.
resultsThe study analyzed 686 patients, 70 who were converted to dCRT (dCRT group) and 616 who underwent surgery (Surg group). The dCRT group had a poorer prognosis than the Surg group, with more advanced tumors and poorer response to NAC. Therefore, further analysis was performed by categorizing patients as Responders (complete or partial response) and Non-responders (stable or progressive disease) to NAC. Among the Responders in the dCRT group, 76.7 % achieved a complete response, and the 5-year esophageal preservation survival rate was 66.9 %. The 5-year survival rates for Responders were 77.5 % in the dCRT group and 71.3 % in the Surg group. Multivariable analysis showed that dCRT did not worsen prognosis (P = 0.706; hazard ratio, 1.13; 95 % confidence interval, 0.59-2.16). Conversely, among the Non-responders, dCRT had a significantly poorer prognosis, with 5-year survival rates of 22.3 % in the dCRT group and 45.1 % in the Surg group (P < 0.001).
conclusionsFor patients responding to NAC, conversion to dCRT is considered a potential treatment option.
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