Evidence map›Paper›PMID 39953324›Full record

ArticleCardiovascular toxicology2025

RNF146 Alleviates Myocardial Ischemia/Reperfusion Injury by Regulating the Ubiquitination-Mediated Degradation of DAPK1 to Inhibit Ferroptosis.

Xiangdong Qiu, Pengfei Yan, Qingyu Zhao, Lehong Yuan

Abstract read
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In one paragraph

Article in Cardiovascular toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xiangdong QiuDepartment of Emergency, The Third Xiangya Hospital of Central South University, 138 Tong Zipo Rd, Changsha, 410013, Hunan, People's Republic of China.
Pengfei YanDepartment of Emergency, People's Hospital of Xiangxi Autonomous Prefecture, Jishou, 416000, Hunan, People's Republic of China.
Qingyu ZhaoDepartment of Emergency, The Third Xiangya Hospital of Central South University, 138 Tong Zipo Rd, Changsha, 410013, Hunan, People's Republic of China.
Lehong YuanDepartment of Emergency, The Third Xiangya Hospital of Central South University, 138 Tong Zipo Rd, Changsha, 410013, Hunan, People's Republic of China. yuanlehong0281@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ring finger protein 146 (RNF146) participates in regulating ferroptosis and ferroptosis is involved in myocardial ischemia/reperfusion injury (MI/RI). However, the effects and mechanisms of RNF146 in MI/RI are still unclear. TTC, H&E, IHC, DHE stainings, and echocardiography technology were used to determine the myocardial infarction area, pathological injury, level of RNF146, ROS, and cardiac function parameters, respectively. CCK-8 was employed to determine the cell viability. The corresponding kits, RT-qPCR, and western blot were adopted to determine the levels of CK-MB, LDH, Fe

Indexed as

Death-Associated Protein KinasesFerroptosisMyocardial InfarctionMyocardial Reperfusion InjuryMyocytes, CardiacUbiquitin-Protein LigasesAnimalsDisease Models, AnimalHumansMaleMiceMice, Inbred C57BLProteolysisSignal TransductionUbiquitinationVentricular Function, LeftDapk1 protein, mouseDeath-Associated Protein KinasesUbiquitin-Protein LigasesDAPK1FerroptosisMyocardial ischemia/reperfusion injuryRNF146Ubiquitination

Identifiers

PMID39953324

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.