ArticleAging clinical and experimental research2025
Left atrial size and echocardiographic diastolic parameters as predictors of incident atrial fibrillation in older hospitalized patients.
Article in Aging clinical and experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Development and Validation of an Explainable Machine Learning Model for Predicting Repeat Catheter Ablation for Atrial Fibrillation: A Single-Center Retrospective Cohort Study.International journal of general medicine · 2026Article
- The left atrium in heart failure with preserved ejection fraction: What we know and what we do not know.Heart rhythm O2 · 2025Review
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11 authors.
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Abstract
backgroundThe associations between left atrial (LA) size, echocardiographic diastolic parameter (E/A ratio), and incident atrial fibrillation (AF) in older inpatients remain underexplored.
aimsThis study aimed to evaluate the relationship between LA size, E/A ratio, and AF risk in older hospitalized patients.
methodsBetween January 2015 and May 2023, a total of 2,615 older inpatients (aged ≥ 65 years) were enrolled in this retrospective longitudinal study. Left atrial diameter (LAD) and E/A ratio were measured using transthoracic echocardiography.
resultsOver a median follow-up of 844 days (IQR: 331-1355 days), 209 patients (8.0%) experienced at least one incident of AF. After adjusting for covariates, large LA and high E/A ratio were significantly associated with incident AF, with an 11% increase in risk for each 1 mm increase in LAD over 35 mm (adjusted HR: 1.11, 95% CI: 1.10-1.13) and a 30% increased risk per standard deviation increase in E/A ratio when E/A ratio exceeded 0.65 (adjusted HR: 1.30, 95% CI: 1.23-1.37), P < 0.001. The influence of LA size and E/A ratio on incident AF was more pronounced in the younger subgroup of older adults. Incorporating LAD and E/A ratios into the CHA2DS2-VASc score improved its predictive accuracy (AUC DISCUSSION: This study shows that LA size and E/A ratio are key predictors of AF in hospitalized older patients, with age influencing their predictive value. Incorporating these factors into the CHA2DS2-VASc score enhances risk stratification and highlights the need for early AF screening in this group.
conclusionsIn hospitalized older patients, large LA and high E/A ratio are associated with incident AF, and these associations are more pronounced in younger individuals. LAD and E/A ratios provide incremental predictive value for AF beyond the CHA2DS2-VASc score.
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