ArticleThe international journal of cardiovascular imaging2025
The prognostic value of CMR diastolic parameters in patients with cardiac light-chain amyloidosis: a retrospective analysis.
Article in The international journal of cardiovascular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prognostic value of left atrial function in cardiac amyloidosis: a systematic review and meta‑analysis.The international journal of cardiovascular imaging · 2026Pooled it
- Application of Left Atrial Strain Based on Cardiac Magnetic Resonance Feature Tracking in Cardiovascular Diseases.Reviews in cardiovascular medicine · 2026Review
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Authors and funding
12 authors.
Funding
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Abstract
Cardiac light-chain amyloidosis (AL-CA), characterized by the accumulation of amyloid fibers in the myocardium, often results in progressive diastolic dysfunction and adverse clinical outcomes. This study aimed to explore the diastolic characteristics of AL-CA using feature tracking cardiac magnetic resonance (CMR) and determine the prognostic parameters for all-cause mortality in such patients. A total of 102 AL-CA patients who underwent CMR between January 2014 and September 2018 were retrospectively reviewed, participations were follow-up until 2021. According to the inclusion and exclusion criteria, 60 patients were ultimately included. All-cause mortality was set as the primary endpoint. Healthy subjects were selected as controls. AL-CA patients were classified as the non-survival and survival group. The baseline characteristics, as well as the CMR-derived LV diastolic strain rate and LA diastolic parameters (LA volume, phasic EF, phasic strain, and strain rate), of survivors, non-survivors, and controls were compared. The associations of diastolic parameters with clinical outcomes were assessed via Cox regression and Kaplan‒Meier analyses. At a median follow-up of 7 months (interquartile range, 2-28 months), 43 (71.6%) cases of all-cause mortality were observed. Compared with controls, non-survivors presented significantly variation for all diastolic parameters (all P < 0.05), with LA volume indexes, LSRconduit and LSRpump value significantly increased and the remaining diastolic functional values significantly decreased. Compared with survivors, non-survivors presented significantly lower LV eGLSR, eGCSR, aGLSR, and selected LA diastolic parameters, including the LA phasic ejection fraction, LA phasic longitudinal strain, and LA longitudinal reservoir strain rate (all P < 0.05); moreover, LA volume indices and LA longitudinal conduit and booster‒pump strain rate values were significantly higher in the non-survival group. Multivariate Cox regression identified LA LSR as a significant predictor of all-cause mortality (hazard ratio, 14.35; 95% CI: 1.44-142.85, p < 0.05), with an optimal cutoff of -0.28 s
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