ArticleScientific reports2025
Gait impairment associated with neuroimaging biomarkers in Alzheimer's disease.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Dual Dopaminergic and Limbic-Cognitive Contributions to Gait Parameters in De Novo Parkinson Disease.Neurology · 2026Article
- Behavioral characterization of olfactory, auditory, and motor deficits in 5×FAD mice.Journal of veterinary science · 2026Article
- Association of gait, balance, and fall risk with dementia in Down syndrome: a systematic review of the literature.Dementia & neuropsychologia · 2026Review
- Using AI-Based Gait Analysis to Establish a 5-Meter Walk Time Cutoff for Discriminating Alzheimer's Disease.Cureus · 2025Article
- Gait-Based Screening for Cognitive Impairment in Older Adults: A Fast and Objective Approach.Healthcare (Basel, Switzerland) · 2025Article
- Voxel- and surface-based morphometry in the cortical thickness and cortical and subcortical gray matter volume in patients with mild-to-moderate Alzheimer's disease.Frontiers in aging neuroscience · 2025Article
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Authors and funding
9 authors.
Funding
Abstract
Research links gait impairment in Alzheimer's disease (AD) to cognitive abnormalities, brain atrophy, or amyloid-β (Aβ) deposition, with the exact cause unclear. This study investigated the relationship between gait, neuroimaging biomarkers, and cognition across the AD spectrum. We recruited 48 AD dementia patients, 27 with prodromal AD, and 41 cognitively unimpaired individuals, analyzing associations among gait parameters, cognitive scores, Aβ deposition, and cortical atrophy. Path and receiver operating characteristic (ROC) analyses evaluated gait impairment's interdependent interactions and diagnostic potential. Prodromal AD and AD dementia patients showed significantly slower gait pace than CU (p = 0.014 [velocity], p = 0.003 [step length]), linked to attention and executive functions, widespread Aβ deposition, and cortical atrophy, in the inferior parietal lobule, middle temporal gyrus, precuneus, and insula. Compared to CU, AD dementia patients exhibited greater gait variability and phase (p = 0.017 [step length standard deviation], p = 0.001 [double support percentage]), significantly correlated with cognition and Aβ deposition. Path analysis revealed a combined influence of Aβ deposition, cognitive impairment, and cortical atrophy on gait impairment, with > 80% observed gait impairments directly affected by Aβ deposition. ROC curves for diagnosing AD stages showed significant areas under the curve, suggesting gait characteristics as noninvasive biomarkers for early AD diagnosis and progression monitoring.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.