Evidence map›Paper›PMID 39953282›Full record

ArticleCommunications biology2025

DNA methylation differences between cord and adult white blood cells reflect postnatal immune cell maturation.

Meaghan J Jones, Chaini Konwar, Rebecca Asiimwe, Louie Dinh, Hamid Reza Razzaghian, Olivia de Goede, Julia L MacIsaac, Alexander M Morin, Kurt P Kolsun, Kristina Gervin and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Meaghan J Jones *Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB, Canada.ORCID http://orcid.org/0000-0003-1593-997X
Chaini Konwar *Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Rebecca AsiimweDepartment of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Louie DinhDepartment of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Hamid Reza RazzaghianBC Children's Hospital Research Institute, Vancouver, BC, Canada.
Olivia de GoedeDepartment of Genetics, Stanford University, Stanford, CA, USA.
Julia L MacIsaacDepartment of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Alexander M MorinDepartment of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Kurt P KolsunDepartment of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB, Canada.ORCID http://orcid.org/0000-0002-0095-5582
Kristina GervinDivision of Clinical Neuroscience, Department of Research and Innovation, Oslo University Hospital, Oslo, Norway.
Robert LyleDepartment of Medical Genetics, Oslo University Hospital, Oslo, Norway.
Raymond T NgDepartment of Computer Science, University of British Columbia, Vancouver, BC, Canada.
Devin C KoestlerDepartment of Biostatistics & Data Science, University of Kansas Medical Center, Kansas City, KS, USA.
Janine F FelixGeneration R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0002-9801-5774
Pascal M LavoieBC Children's Hospital Research Institute, Vancouver, BC, Canada.ORCID http://orcid.org/0000-0002-2205-0362
Wendy P RobinsonDepartment of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Sara MostafaviDepartment of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Michael S KoborDepartment of Medical Genetics, University of British Columbia, Vancouver, BC, Canada. michael.kobor@ubc.ca.ORCID http://orcid.org/0000-0003-4140-1743

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epigenetic modifications such as DNA methylation are both cell type and developmental age specific. Here, we show that the immunological maturation of blood cell types influences DNA methylation changes from naive cord blood to fully functional adult blood. Lymphoid cells in adult blood showed more variability than in cord blood suggesting an antigen-dependent maturation of DNA methylation in lymphoid cells throughout the lifespan. Fewer DNA methylation changes between cord and adult blood were observed in myeloid cells, particularly in monocytes, which demonstrated the least number of DNA methylation changes between cord and adult blood. We also noted differences in epigenetic ages by immune cell types within the same individuals, specifically in cord blood where monocytes were epigenetically oldest compared to the other cell types. In addition, we provide a publicly available resource to the community as an R Shiny web application to interactively explore epigenetic patterns between naive cord white blood cells and fully functional adult white blood cells for six immune cell types.

Indexed as

DNA MethylationEpigenesis, GeneticFetal BloodLeukocytesAdultFemaleHumansMaleYoung Adult

Identifiers

PMID39953282
PMCPMC11828917

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.