Evidence map›Paper›PMID 39953276›Full record

ArticleNature cardiovascular research2025

TRPM7 channel activity promotes the pathogenesis of abdominal aortic aneurysms.

Pengyu Zong, Cindy X Li, Jianlin Feng, Zhichao Yue, Thushara Nethramangalath, Yangzhouyun Xie, Xin Qin, Mara Cicchetti, Yujun Cai, Evan Jellison and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature cardiovascular research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Pengyu Zong *Department of Cell Biology, Calhoun Cardiology Center, University of Connecticut School of Medicine (UConn Health), Farmington, CT, USA.
Cindy X Li *Department of Cell Biology, Calhoun Cardiology Center, University of Connecticut School of Medicine (UConn Health), Farmington, CT, USA.
Jianlin Feng *Department of Cell Biology, Calhoun Cardiology Center, University of Connecticut School of Medicine (UConn Health), Farmington, CT, USA.
Zhichao YueDepartment of Cell Biology, Calhoun Cardiology Center, University of Connecticut School of Medicine (UConn Health), Farmington, CT, USA.
Thushara NethramangalathDepartment of Pharmacology, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA.
Yangzhouyun XieDivision of Vascular Surgery and Endovascular Therapy, Department of Surgery, Yale School of Medicine, New Haven, CT, USA.
Xin QinDepartment of Cell Biology, Calhoun Cardiology Center, University of Connecticut School of Medicine (UConn Health), Farmington, CT, USA.
Mara CicchettiDepartment of Cell Biology, Calhoun Cardiology Center, University of Connecticut School of Medicine (UConn Health), Farmington, CT, USA.
Yujun CaiDivision of Vascular Surgery and Endovascular Therapy, Department of Surgery, Yale School of Medicine, New Haven, CT, USA.
Evan JellisonDepartment of Immunology, University of Connecticut School of Medicine (UConn Health), Farmington, CT, USA.ORCID http://orcid.org/0009-0004-2674-1605
Masayuki MatsushitaDepartment of Molecular and Cellular Physiology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan.
Loren W RunnelsDepartment of Pharmacology, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA. runnellw@rwjms.rutgers.edu.ORCID http://orcid.org/0000-0002-2537-7360
Lixia YueDepartment of Cell Biology, Calhoun Cardiology Center, University of Connecticut School of Medicine (UConn Health), Farmington, CT, USA. lyue@uchc.edu.ORCID http://orcid.org/0000-0002-3558-091X

Funding

Calcium Signaling Mechanisms in Cardiac FibrogenesisR01HL171486 · NHLBI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Lixia Yue · 2024 to 2026
$2.0M
Transient Receptor Potential Melastatin 2 (TRPM2) in Ischemic StrokeR01NS131661 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Lixia Yue · 2024 to 2026
$1.3M
NHLBI NIH HHS R01 HL171486NINDS NIH HHS R01 NS131661U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) NIHr01 NS131661U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01-HL143750U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL171485
6 · The paper itself

Abstract

Abdominal aortic aneurysms (AAAs) occur in 1-2% of the elderly. The rupture of an AAA usually causes uncontrollable lethal hemorrhage, and its risk increases with AAA size. However, there is no effective pharmacological therapy for hindering AAA growth. Here we show that global or vascular smooth muscle cell (VSMC)-specific transient receptor potential melastatin 7 (TRPM7) knockout in mice prevented AAA formation, as indicated by inhibited VSMC reprogramming, reduced inflammatory infiltration and suppressed matrix degradation. Mechanistically, we showed that TRPM7-mediated Ca

Indexed as

Aorta, AbdominalAortic Aneurysm, AbdominalMuscle, Smooth, VascularMyocytes, Smooth MuscleProtein Serine-Threonine KinasesTRPM Cation ChannelsVascular RemodelingAnimalsCalcium SignalingCells, CulturedDisease Models, AnimalHumansKruppel-Like Factor 4Kruppel-Like Transcription FactorsMaleMiceKlf4 protein, mouseKruppel-Like Factor 4Kruppel-Like Transcription FactorsProtein Serine-Threonine KinasesTrpm7 protein, mouseTRPM Cation Channels

Identifiers

PMID39953276
PMCPMC12143175

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.