Evidence map›Paper›PMID 39953247›Full record

ArticleJournal of gastroenterology2025

Diagnostic accuracy and cut-off values of serum leucine-rich alpha-2 glycoprotein for Crohn's disease activity in the small bowel.

Muneyori Okita, Kento Takenaka, Fumihito Hirai, Shinya Ashizuka, Hideki Iijima, Shigeki Bamba, Toshimitsu Fujii, Kenji Watanabe, Yosuke Shimodaira, Hisashi Shiga and 5 more

Abstract readEvaluation StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Muneyori OkitaDepartment of Biostatistics, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya, Aichi, 466-8550, Japan. muneyoriokita@gmail.com.ORCID 0000-0002-6291-1235
Kento TakenakaDepartment of Gastroenterology and Hepatology, Institute of Science Tokyo, Tokyo, Japan.
Fumihito HiraiDepartment of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, Fukuoka, Japan.
Shinya AshizukaDepartment of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, Fukuoka, Japan.
Hideki IijimaOsaka International Medical & Science Center, Osaka Keisatsu Hospital, Osaka, Japan.
Shigeki BambaDepartment of Fundamental Nursing, Shiga University of Medical Science, Shiga, Japan.
Toshimitsu FujiiDepartment of Gastroenterology and Hepatology, Institute of Science Tokyo, Tokyo, Japan.
Kenji WatanabeDepartment of Internal Medicine for Inflammatory Bowel Disease, Toyama University, Toyama, Japan.
Yosuke ShimodairaDepartment of Gastroenterology and Neurology, Akita University Graduate School of Medicine, Akita, Japan.
Hisashi ShigaDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Miyagi, Japan.
Sakiko HiraokaDepartment of Gastroenterology and Hepatology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Okayama, Japan.
Toshihiro InokuchiResearch Center for Intestinal Health Science, Okayama University, Okayama, Japan.
Takeshi YamamuraDepartment of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya, Aichi, 466-8550, Japan.
Ryo EmotoDepartment of Biostatistics, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya, Aichi, 466-8550, Japan.
Shigeyuki MatsuiDepartment of Biostatistics, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya, Aichi, 466-8550, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSmall bowel (SB) lesions in Crohn's disease (CD) are often asymptomatic despite being highly active. Fecal calprotectin (FC) is the most widely used biomarker of CD activity, but its drawbacks include a large intra-individual sample variability and the burden of collecting stool samples. Meanwhile, serum leucine-rich alpha-2 glycoprotein (LRG) has recently attracted attention as a biomarker that can address the limitations of FC. This study determined the diagnostic accuracy of LRG and its cut-off values for diagnosing CD activity in SB.

methodsThis was a retrospective, multi-center study of CD patients undergoing retrograde balloon-assisted endoscopy. For ileal- and ileocolonic-type patients with a colon SES-CD score of 0, we estimated the receiver operating characteristic curve of LRG and determined the cut-off value to achieve a target sensitivity level of 80%.

resultsAmong 285 patients with SB lesions, LRG had an area under the curve (AUC) of 0.72 (95% CI 0.67-0.78) with a sensitivity of 80.2% and specificity of 47.2% for a cut-off value of 10.5 when diagnosing endoscopic remission (modified SES-CD ≤ 3), while it had an AUC of 0.72 (95% CI 0.65-0.78) with a sensitivity of 81.2% and specificity of 46.2% for a cut-off value of 10.1 when diagnosing complete ulcer healing (modified SES-CD ≤ 1).

conclusionLRG was effective for diagnosing CD activity in SB, specifically with cut-off values of 10.5 and 10.1 for endoscopic remission and complete ulcer healing, respectively. A future prospective validation study will assess its clinical utility.

Indexed as

Crohn DiseaseGlycoproteinsIntestine, SmallAdultAgedArea Under CurveBiomarkersFemaleHumansLeukocyte L1 Antigen ComplexMaleMiddle AgedRetrospective StudiesROC CurveSensitivity and SpecificitySeverity of Illness IndexBiomarkersGlycoproteinsLeukocyte L1 Antigen ComplexLRG1 protein, humanBiomarkerCrohn’s diseaseLRG

Identifiers

PMID39953247
PMCPMC12014797

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.