Evidence map›Paper›PMID 39953146›Full record

ArticleNPJ digital medicine2025

Improving medical machine learning models with generative balancing for equity and excellence.

Brandon Theodorou, Benjamin Danek, Venkat Tummala, Shivam Pankaj Kumar, Bradley Malin, Jimeng Sun

Abstract read
In one paragraph

Article in NPJ digital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Brandon TheodorouUniversity of Illinois at Urbana-Champaign, Urbana, IL, USA.
Benjamin DanekUniversity of Illinois at Urbana-Champaign, Urbana, IL, USA.
Venkat TummalaUniversity of Illinois at Urbana-Champaign, Urbana, IL, USA.
Shivam Pankaj KumarUniversity of Illinois at Urbana-Champaign, Urbana, IL, USA.
Bradley MalinVanderbilt University, Nashville, TN, USA.
Jimeng SunUniversity of Illinois at Urbana-Champaign, Urbana, IL, USA. jimeng@illinois.edu.

Funding

National Science Foundation, USA SCH-2205289
6 · The paper itself

Abstract

Applying machine learning to clinical outcome prediction is challenging due to imbalanced datasets and sensitive tasks that contain rare yet critical outcomes and where equitable treatment across diverse patient groups is essential. Despite attempts, biases in predictions persist, driven by disparities in representation and exacerbated by the scarcity of positive labels, perpetuating health inequities. This paper introduces FairPlay, a synthetic data generation approach leveraging large language models, to address these issues. FairPlay enhances algorithmic performance and reduces bias by creating realistic, anonymous synthetic patient data that improves representation and augments dataset patterns while preserving privacy. Through experiments on multiple datasets, we demonstrate that FairPlay boosts mortality prediction performance across diverse subgroups, achieving up to a 21% improvement in F1 Score without requiring additional data or altering downstream training pipelines. Furthermore, FairPlay consistently reduces subgroup performance gaps, as shown by universal improvements in performance and fairness metrics across four experimental setups.

Identifiers

PMID39953146
PMCPMC11828851

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.