ArticleScientific reports2025
Performance of homozygosity by descent in two mice lines divergently selected for birth weight environmental variability.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Inbreeding can have negative effects, such as increasing the expression of deleterious alleles or reducing fitness. A method based on Hidden Markov Models (HMM) was developed to determine the probability of an individual genome in a homozygous-by-descent state (HBD). As a result of an experiment of divergent selection for birth weight environmental variability two lines were created: high variability line (H-Line) and low variability line (L-Line). The L-Line demonstrated a better performance in traits related with robustness than the H-Line. From a selection period of 20 generations, a total of 655 individuals from the H-Line and 675 individuals from the L-Line were genotyped with a high-density SNP array. We used a predefined multiclass HMM with a total of 9 age related HBD classes and 1 non HBD class. The sum of the probabilities of each HBD class was defined as the total HBD inbreeding (F
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