Evidence map›Paper›PMID 39952985›Full record

ReviewNPJ Regenerative medicine2025

Advancements in bioengineering for descemet membrane endothelial keratoplasty (DMEK).

Sarah Barbara Zwingelberg, Gizem Karabiyik, Paul Gehle, Melanie von Brandenstein, Sabina Eibichova, Christian Lotz, Florian Groeber-Becker, Daniel Kampik, Ula Jurkunas, Gerd Geerling and 1 more

Abstract readReview
In one paragraph

Review in NPJ Regenerative medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Type VIII collagen: advances in matrix biology and translational promise.Frontiers in bioengineering and biotechnology · 2025
    Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sarah Barbara ZwingelbergDepartment of Ophthalmology, University Hospital of Duesseldorf, Duesseldorf, Germany. sarah.zwingelberg@med.uni-duesseldorf.de.
Gizem KarabiyikDepartment of Functional Materials in Medicine and Dentistry, University Hospital Würzburg, Würzburg, Germany.
Paul GehleDepartment of Urology, University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany.
Melanie von BrandensteinDepartment of Urology, University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany.
Sabina EibichovaUniversity Hospital Würzburg, Department of Tissue Engineering and Regenerative Medicine, Würzburg, Germany.
Christian LotzUniversity Hospital Würzburg, Department of Tissue Engineering and Regenerative Medicine, Würzburg, Germany.
Florian Groeber-BeckerDepartment of Ophthalmology, University Hospital of Duesseldorf, Duesseldorf, Germany.
Daniel KampikDepartment of Ophthalmology, University Hospital Würzburg, Würzburg, Germany.
Ula JurkunasDepartment of Ophthalmology, Harvard Medical School, Schepens Eye Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0002-5059-608X
Gerd GeerlingDepartment of Ophthalmology, University Hospital of Duesseldorf, Duesseldorf, Germany.
Gregor LangDepartment of Functional Materials in Medicine and Dentistry, University Hospital Würzburg, Würzburg, Germany. gregor.lang@uni-wuerzburg.de.ORCID http://orcid.org/0000-0001-9819-8630

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Corneal diseases are the third leading cause of blindness worldwide. Descemet's Membrane Endothelial Keratoplasty (DMEK) is the preferred surgical technique for treating corneal endothelial disorders, relying heavily on high-quality donor tissue. However, the scarcity of suitable donor tissue and the sensitivity of endothelial cells remain significant challenges. This review explores the current state of DMEK, focusing on advancements in tissue engineering as a promising solution to improve outcomes and address donor limitations.

Identifiers

PMID39952985
PMCPMC11828897

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.