Evidence map›Paper›PMID 39952983›Full record

ArticleScientific reports2025

Genome-wide identification and functional validation of the WW domain containing oxidoreductase gene associated with sleep duration.

Soriul Kim, So Who Kang, Song E Kim, Hyeon Jin Kim, Sol Ah Kim, Yae Won Lee, Eun Young Kim, Chol Shin, Hyang Woon Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Soriul Kim *Department of Paramedicine, Seowon University, Cheongju, South Korea.
So Who Kang *Department of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon, South Korea.
Song E KimDepartments of Neurology and Medical Science, Computational Medicine, System Health Science and Engineering and Artificial Intelligence Graduate Programs, Ewha Womans University School of Medicine and Ewha Medical Research Institute, 1071, Anyangcheon-ro, Yangcheon-gu, Seoul, 07985, South Korea.
Hyeon Jin KimInstitute for Human Genomic Study, College of Medicine, Korea University, Seoul, South Korea.
Sol Ah KimDepartments of Neurology and Medical Science, Computational Medicine, System Health Science and Engineering and Artificial Intelligence Graduate Programs, Ewha Womans University School of Medicine and Ewha Medical Research Institute, 1071, Anyangcheon-ro, Yangcheon-gu, Seoul, 07985, South Korea.
Yae Won LeeDepartments of Neurology and Medical Science, Computational Medicine, System Health Science and Engineering and Artificial Intelligence Graduate Programs, Ewha Womans University School of Medicine and Ewha Medical Research Institute, 1071, Anyangcheon-ro, Yangcheon-gu, Seoul, 07985, South Korea.
Eun Young KimDepartment of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon, South Korea.
Chol Shin *Institute for Human Genomic Study, College of Medicine, Korea University, Seoul, South Korea. chol-shin@korea.ac.kr.
Hyang Woon Lee *Departments of Neurology and Medical Science, Computational Medicine, System Health Science and Engineering and Artificial Intelligence Graduate Programs, Ewha Womans University School of Medicine and Ewha Medical Research Institute, 1071, Anyangcheon-ro, Yangcheon-gu, Seoul, 07985, South Korea. leeh@ewha.ac.kr.

Funding

Institute of Information & Communications Technology Planning & Evaluation RS-2022-00155966Korea Disease Control and Prevention Agency 2001-347-6111-221Korea Health Industry Development Institute HI20C0469Korea Health Industry Development Institute RS-2024-00440131National Research Foundation of Korea NRF-2017R1A6A3A11034663National Research Foundation of Korea NRF-2019M3C1B8090803
6 · The paper itself

Abstract

Individual differences in sleep duration have been reported, and genetic components of sleep duration have been identified showing various heritability. To identify genetic variants that contribute to sleep duration, we conducted a human genome-wide identification on sleep duration and performed confirmatory experiments using a Drosophila model. Genome-wide association study in human was analyzed to determine the association of the genetic variants with self-aware sleep duration from two community-based cohort, Ansan (cohort 1, n = 4635) and Ansung (cohort 2, n = 4205), recruited from the Korean Genome and Epidemiology Study. Individual single nucleotide variants (rs16948804 and rs4887991) in the WW domain containing oxidoreductase (WWOX) gene were associated with self-aware sleep duration in human (p-values, 1.11 × 10

Indexed as

Genome-Wide Association StudySleepTumor Suppressor ProteinsWW Domain-Containing OxidoreductaseAdultAnimalsDrosophilaFemaleHumansMaleMiddle AgedPolymorphism, Single NucleotideSleep DurationTumor Suppressor ProteinsWW Domain-Containing OxidoreductaseWWOX protein, humanDrosophilaGenome-wide association studyLoss-of-functionSleep durationWWOX

Identifiers

PMID39952983
PMCPMC11828923

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.