Evidence map›Paper›PMID 39952954›Full record

ArticleScientific data2025

OCT5k: A dataset of multi-disease and multi-graded annotations for retinal layers.

Mustafa Arikan, James Willoughby, Sevim Ongun, Ferenc Sallo, Andrea Montesel, Hend Ahmed, Ahmed Hagag, Marius Book, Henrik Faatz, Maria Vittoria Cicinelli and 8 more

Abstract readDataset
In one paragraph

Article in Scientific data, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Mustafa ArikanUCL, Institute of Ophthalmology, London, EC1V 9EL, UK.ORCID http://orcid.org/0000-0002-5386-7447
James WilloughbyUCL, Institute of Ophthalmology, London, EC1V 9EL, UK.
Sevim OngunUCL, Institute of Ophthalmology, London, EC1V 9EL, UK.
Ferenc SalloJules Gonin Eye Hospital, Department of Ophthalmology, University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0003-4313-3965
Andrea MonteselJules Gonin Eye Hospital, Department of Ophthalmology, University of Lausanne, Lausanne, Switzerland.
Hend AhmedUniversity College London Hospitals NHS Foundation Trust, London, UK.
Ahmed HagagUCL, Institute of Ophthalmology, London, EC1V 9EL, UK.
Marius BookRare Retinal Disease Center, AugenZentrum Siegburg, Siegburg, Germany.ORCID http://orcid.org/0000-0002-5178-8673
Henrik FaatzEye Center at St. Franziskus Hospital Münster, Münster, Germany.ORCID http://orcid.org/0000-0002-5363-0052
Maria Vittoria CicinelliDepartment of Ophthalmology, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID http://orcid.org/0000-0003-2938-0409
Amani A FawziNorthwestern University Medical School, Chicago, US.
Dominika PodkowinskiDepartment of Ophthalmology, Kepler University Clinic, Linz, Austria and Vienna Institute for Research in Ocular Surgery (VIROS), Hanusch Hospital, Vienna, Austria.
Marketa CilkovaMoorfields Eye Hospital NHS Foundation, NIHR Moorfields Biomedical Research Centre, London, EC1V 2PD, UK.
Diana Morais De AlmeidaJules Gonin Eye Hospital, Department of Ophthalmology, University of Lausanne, Lausanne, Switzerland.
Moussa ZouacheDepartment of Ophthalmology & Visual Sciences, University of Utah, Salt Lake City, USA.
Ganesham RamsamyWest Midlands NHS Trust, London, UK.
Watjana Lilaonitkul *UCL, Global Business School for Health, London, WC1E 6BT, UK.
Adam M Dubis *UCL, Institute of Ophthalmology, London, EC1V 9EL, UK. a.dubis@ucl.ac.uk.

Funding

University of Utah, Core Vision Research GrantP30EY014800 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jun Yang · 2005 to 2026
$14.6M
NEI NIH HHS P30 EY014800
6 · The paper itself

Abstract

Publicly available open-access OCT datasets for retinal layer segmentation have been limited in scope, often being small in size, specific to a single disease, or containing only one grading. This dataset improves upon this with multi-grader and multi-disease labels for training machine learning-based algorithms. The proposed dataset covers three subsets of scans (Age-related Macular Degeneration, Diabetic Macular Edema, and healthy) and annotations for two types of tasks (semantic segmentation and object detection). This dataset compiled 5016 pixel-wise manual labels for 1672 OCT scans featuring 5 layer boundaries for three different disease classes to support development of automatic techniques. A subset of data (566 scans across 9 classes of disease biomarkers) was subsequently labeled for disease features for 4698 bounding box annotations. To minimize bias, images were shuffled and distributed among graders. Retinal layers were corrected, and outliers identified using the interquartile range (IQR). This step was iterated three times, improving layer annotations' quality iteratively, ensuring a reliable dataset for automated retinal image analysis.

Indexed as

RetinaTomography, Optical CoherenceAlgorithmsHumansImage Processing, Computer-AssistedMachine LearningMacular DegenerationMacular Edema

Identifiers

PMID39952954
PMCPMC11829038

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.