ArticleNature communications2025
Matrix mechano-sensing at the invasive front induces a cytoskeletal and transcriptional memory supporting metastasis.
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Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35citing papers in PubMed
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35 citing papers in PubMed.
- Review
- Integrated collagen architecture and composition improve risk stratification in triple-negative breast cancer.Neoplasia (New York, N.Y.) · 2026Article
- Epithelial-mesenchymal transition in carcinoma: navigating phenotypic states to target resistance and metastasis.Cancer metastasis reviews · 2026Review
- Biofabrication for spatial control of multiscale biological crosstalk in tissue models.npj biomedical innovations · 2026Review
- Neural regulation of cancer: from microenvironmental hijacking to systemic circuit co-option.Cellular oncology (Dordrecht, Netherlands) · 2026Review
- Tumor-infiltrating B cells evolve towards interferon-rich trajectories aligned with immunotherapy in melanoma.Journal of experimental & clinical cancer research : CR · 2026Article
- Beyond DNA damage: 3D tumor models and the integrin mechanobiology of radioresistance.Journal of experimental & clinical cancer research : CR · 2026Review
- Nanomedicine targeting ECM stiffness: restoring mechanical homeostasis for cancer immunotherapy.Materials today. Bio · 2026Review
- Deconvolution in Alzheimer's disease.Neural regeneration research · 2026Article
- Extracellular matrix stiffness directs region-specific lung epithelial differentiation revealed by hPSC-derived lung organoids.Nature communications · 2026Article
- The PLAU-ITGB1-TGF-β axis orchestrates spatiotemporal reprogramming of fibroblasts at the invasive front to drive dual immunosuppressive niche and immunotherapy resistance in oral squamous cell carcinoma.Cell death & disease · 2026Article
- NGFR induces melanoma invasion and immunotherapy resistance through myosin light chain 2 modulation.The EMBO journal · 2026Article
- Developing a melanoma-skin-on-a-chip integrated with vasculature using an edgeless skin reconstruction approach.Research square · 2026Article
- Pan-cancer analysis reveals Rho kinase addiction as a vulnerability of de-differentiated cancer cells.iScience · 2026Article
- Rewiring tumor metabolism: heterogeneity, oncometabolites, and adaptive plasticity.Experimental hematology & oncology · 2026Review
- Photothermal-detonated functional macrophage membrane-camouflaged nano-crackers induce tumor cell wandering-anoikis.Asian journal of pharmaceutical sciences · 2026Article
- Amoeboid cancer cells at a glance.Journal of cell science · 2026Review
- Integrated Collagen Architecture and Composition Improve Risk Stratification in Triple-Negative Breast Cancer.bioRxiv : the preprint server for biology · 2026Article
- CellNiche represents cellular microenvironments in atlas-scale spatial omics data with contrastive learning.Nature communications · 2026Article
- Amoeboid-mesenchymal transition and the proteolytic control of cancer invasion plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
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Authors and funding
35 authors.
Oscar MaiquesCytoskeleton and metastasis Team, The Breast Cancer Now Toby Robins Research Centre Division of Breast Cancer Research, The Institute of Cancer Research, Chester Beatty Laboratories, London, SW3 6JB, UK.ORCID http://orcid.org/0000-0002-2172-4388
Marta C Sallan *Cytoskeleton and metastasis Team, The Breast Cancer Now Toby Robins Research Centre Division of Breast Cancer Research, The Institute of Cancer Research, Chester Beatty Laboratories, London, SW3 6JB, UK.
Roman Laddach *St. John's Institute of Dermatology, School of Basic and Medical Biosciences, King's College London, SE1 9RT, London, UK.
Pahini Pandya *Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London, SE1 1UL, UK.
Adrian VarelaCytoskeleton and metastasis Team, The Breast Cancer Now Toby Robins Research Centre Division of Breast Cancer Research, The Institute of Cancer Research, Chester Beatty Laboratories, London, SW3 6JB, UK.
Eva Crosas-MolistCytoskeleton and metastasis Team, The Breast Cancer Now Toby Robins Research Centre Division of Breast Cancer Research, The Institute of Cancer Research, Chester Beatty Laboratories, London, SW3 6JB, UK.
Jaume BarceloCytoskeleton and metastasis Team, The Breast Cancer Now Toby Robins Research Centre Division of Breast Cancer Research, The Institute of Cancer Research, Chester Beatty Laboratories, London, SW3 6JB, UK.
Olivia CourbotCell and Tissue Mechanobiology Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.ORCID http://orcid.org/0000-0003-4363-3249
Yanbo LiuCytoskeleton and metastasis Team, The Breast Cancer Now Toby Robins Research Centre Division of Breast Cancer Research, The Institute of Cancer Research, Chester Beatty Laboratories, London, SW3 6JB, UK.ORCID http://orcid.org/0000-0003-3272-134X
Vittoria GrazianiCytoskeleton and metastasis Team, The Breast Cancer Now Toby Robins Research Centre Division of Breast Cancer Research, The Institute of Cancer Research, Chester Beatty Laboratories, London, SW3 6JB, UK.ORCID http://orcid.org/0000-0002-8391-2763
Youssef ArafatDepartment of Computer Science, City St George's, University of London, London, UK.ORCID http://orcid.org/0000-0002-2318-6763
Joanne SewellCentre for Tumour Microenvironment, Barts Cancer Institute, Queen Mary University of London, John Vane Science Building, Charterhouse Square, London, EC1M 6BQ, UK.
Irene Rodriguez-HernandezCentre for Tumour Microenvironment, Barts Cancer Institute, Queen Mary University of London, John Vane Science Building, Charterhouse Square, London, EC1M 6BQ, UK.ORCID http://orcid.org/0000-0002-6487-452X
Bruce FanshaweRandall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London, SE1 1UL, UK.
Yaiza Jung-GarciaCytoskeleton and metastasis Team, The Breast Cancer Now Toby Robins Research Centre Division of Breast Cancer Research, The Institute of Cancer Research, Chester Beatty Laboratories, London, SW3 6JB, UK.
Paul Rc ImbertCMR Advanced Bio-imaging Facility, Centre for Microvascular Research, Queen Mary University of London, John Vane Science Building, Charterhouse Square, London, EC1M 6BQ, UK.
Eloise M GrassetUniversity Cote d'Azur, CNRS UMR7284, INSERM U1081, Institute for Research on Cancer and Aging, Nice (IRCAN), Nice, France.
Jean AlbrenguesUniversity Cote d'Azur, CNRS UMR7284, INSERM U1081, Institute for Research on Cancer and Aging, Nice (IRCAN), Nice, France.
Maria SantacanaDepartment of Pathology and Molecular Genetics, Hospital Universitari Arnau de Vilanova, University of Lleida, IRBLleida, CIBERONC, Lleida, 25198, Spain.
Anna MaciàOncologic Pathology Group, IRBLleida, Departments of Experimental Medicine and Basic Medical Sciences, University of Lleida, Lleida, 25198, Spain.
Jordi TarragonaDepartment of Pathology and Molecular Genetics, Hospital Universitari Arnau de Vilanova, University of Lleida, IRBLleida, CIBERONC, Lleida, 25198, Spain.
Xavier Matias-GuiuDepartment of Pathology and Molecular Genetics, Hospital Universitari Arnau de Vilanova, University of Lleida, IRBLleida, CIBERONC, Lleida, 25198, Spain.ORCID http://orcid.org/0000-0002-7201-6605
Rosa M MartiDepartment of Dermatology, Hospital Universitari Arnau de Vilanova, CIBERONC, University of Lleida, CIBERONC, IRB Lleida, Lleida, 25198, Spain.ORCID http://orcid.org/0000-0001-6866-6114
Sophia TsokaDepartment of Informatics, Faculty of Natural and Mathematical Sciences, King's College London, Bush House, London, WC2B 4BG, UK.
Cedric GaggioliUniversity Cote d'Azur, CNRS UMR7284, INSERM U1081, Institute for Research on Cancer and Aging, Nice (IRCAN), Nice, France.ORCID http://orcid.org/0000-0002-4710-1605
Jose L OrgazCentre for Tumour Microenvironment, Barts Cancer Institute, Queen Mary University of London, John Vane Science Building, Charterhouse Square, London, EC1M 6BQ, UK.
Gilbert O FruhwirthComprehensive Cancer Centre, School of Cancer and Pharmaceutical Sciences, King's College London, London, SE1 1UL, UK.ORCID http://orcid.org/0000-0002-1438-2674
Fredrik WallbergQuell Therapeutics, Translation & Innovation Hub, 84 Wood Ln, London, W12 0BZ, UK.
Kai BetteridgeLight Microscopy Facility, The Institute of Cancer Research, Chester Beatty Laboratories, London, SW3 6JB, UK.
Constantino Carlos Reyes-AldasoroDepartment of Computer Science, City St George's, University of London, London, UK.ORCID http://orcid.org/0000-0002-9466-2018
Syed HaiderBreast Cancer Research Bioinformatics Group, Chester Beatty Laboratories, London, SW3 6JB, UK.
Andrejs BraunCentre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Building, Charterhouse Square, London, EC1M 6BQ, UK.ORCID http://orcid.org/0000-0003-0925-5598
Sophia N KaragiannisSt. John's Institute of Dermatology, School of Basic and Medical Biosciences, King's College London, SE1 9RT, London, UK.ORCID http://orcid.org/0000-0002-4100-7810
Alberto Elosegui-ArtolaDepartment of Computer Science, City St George's, University of London, London, UK.ORCID http://orcid.org/0000-0003-0644-3294
Victoria Sanz-MorenoCytoskeleton and metastasis Team, The Breast Cancer Now Toby Robins Research Centre Division of Breast Cancer Research, The Institute of Cancer Research, Chester Beatty Laboratories, London, SW3 6JB, UK. victoria.sanz-moreno@icr.ac.uk.ORCID http://orcid.org/0000-0002-5096-9456
Funding
No grant is acknowledged in the PubMed record.
Abstract
The extracellular matrix (ECM) controls tumour dissemination. We characterise ECM organization in human and mouse tumours, identifying three regions: tumour body, proximal invasive front and distal invasive front. Invasive areas show increased matrix density, fibre thickness, length, and alignment, with unique radial fibre orientation at the distal invasive front correlating with amoeboid invasive features. Using patient samples and murine models, we find that metastases recapitulate ECM features of the primary tumour. Ex vivo culture of murine cancer cells isolated from the different tumour regions reveals a spatial cytoskeletal and transcriptional memory. Several in vitro models recapitulate the in vivo ECM organisation showing that increased matrix induces 3D confinement supporting Rho-ROCK-Myosin II activity, while radial orientation enhances directional invasion. Spatial transcriptomics identifies a mechano-inflammatory program associated with worse prognosis across multiple tumour types. These findings provide mechanistic insights into how ECM organization shapes local invasion and distant metastasis.
Indexed as
CytoskeletonExtracellular MatrixMechanotransduction, CellularAnimalsCell Line, TumorFemaleGene Expression Regulation, NeoplasticHumansMiceMyosin Type IINeoplasm InvasivenessNeoplasm Metastasisrho-Associated KinasesMyosin Type IIrho-Associated Kinases
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LicenceCC BY-NC-ND
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.