Evidence map›Paper›PMID 39952665›Full record

ArticleAJNR. American journal of neuroradiology2025

Imaging Clusters of Pediatric Low-Grade Glioma Are Associated with Distinct Molecular Characteristics.

Anahita Fathi Kazerooni, Adam Kraya, Komal S Rathi, Meen Chul Kim, Varun Kesherwani, Ryan Corbett, Arastoo Vossough, Nastaran Khalili, Deep Gandhi, Neda Khalili and 15 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Anahita Fathi KazerooniFrom the Center for Data-Driven Discovery in Biomedicine (D3b)(A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania anahitaf@upenn.edu.ORCID https://orcid.org/0000-0001-7131-2261
Adam KrayaFrom the Center for Data-Driven Discovery in Biomedicine (D3b)(A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Komal S RathiFrom the Center for Data-Driven Discovery in Biomedicine (D3b)(A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Meen Chul KimFrom the Center for Data-Driven Discovery in Biomedicine (D3b)(A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Varun KesherwaniFrom the Center for Data-Driven Discovery in Biomedicine (D3b)(A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Ryan CorbettCenter for Cancer and Immunology Research (R.C.), Children's National Hospital, Washington, District of Columbia.
Arastoo VossoughDivision of Radiology (A.V.), Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.ORCID https://orcid.org/0000-0003-1346-427X
Nastaran KhaliliFrom the Center for Data-Driven Discovery in Biomedicine (D3b)(A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Deep GandhiFrom the Center for Data-Driven Discovery in Biomedicine (D3b)(A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Neda KhaliliFrom the Center for Data-Driven Discovery in Biomedicine (D3b)(A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Ariana M FamiliarFrom the Center for Data-Driven Discovery in Biomedicine (D3b)(A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.ORCID https://orcid.org/0000-0002-9315-8653
Run JinFrom the Center for Data-Driven Discovery in Biomedicine (D3b)(A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Xiaoyan HuangFrom the Center for Data-Driven Discovery in Biomedicine (D3b)(A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Yuankun ZhuFrom the Center for Data-Driven Discovery in Biomedicine (D3b)(A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Alex SicklerFrom the Center for Data-Driven Discovery in Biomedicine (D3b)(A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Matthew R LuederFrom the Center for Data-Driven Discovery in Biomedicine (D3b)(A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Saksham PhulFrom the Center for Data-Driven Discovery in Biomedicine (D3b)(A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Phillip B StormFrom the Center for Data-Driven Discovery in Biomedicine (D3b)(A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Jeffrey B WareDepartment of Radiology (A.N., J.B.W.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.ORCID https://orcid.org/0000-0002-3495-9733
Jessica B FosterDivision of Oncology (J.B.F., M.J.F.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Sabine MuellerDepartment of Neurology and Pediatrics (S.M.), University of California San Francisco, San Francisco, California.ORCID https://orcid.org/0000-0002-3452-5150
Jo Lynne RokitaDepartment of Pediatrics (R.C., J.L.R.), The George Washington University, Washington, District of Columbia.
Michael J FisherDivision of Oncology (J.B.F., M.J.F.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Adam C ResnickFrom the Center for Data-Driven Discovery in Biomedicine (D3b)(A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Ali NabavizadehFrom the Center for Data-Driven Discovery in Biomedicine (D3b)(A.F.K., A.K., K.S.R., M.C.K., V.K., Nastaran Khalili, A.M.F., R.J., Neda Khalili, D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R., A.N.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.ORCID https://orcid.org/0000-0002-0380-4552

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeCancers show heterogeneity at various levels, from genome to radiologic imaging. This study aimed to explore the interplay between genomic, transcriptomic, and radiophenotypic data in pediatric low-grade glioma (pLGG), the most common group of brain tumors in children. MATERIALS AND

methodsWe analyzed data from 201 patients with pLGG in the Children's Brain Tumor Network by using principal component analysis and K-means clustering on 881 radiomic features, along with clinical variables (age, sex, tumor location), to identify imaging clusters and examine their association with pLGG classifications as described in the World Health Organization Classification of Tumors of the Central Nervous System, 5th edition, 2021 (WHO 2021 CNS 5). To determine the transcriptome pathways linked to imaging clusters, we employed a supervised machine-learning model with elastic net logistic regression based on the pathways identified through gene set enrichment and gene coexpression network analyses.

resultsThree imaging clusters with distinct radiomic characteristics were identified.

conclusionsOur radiogenomics study indicates that the intrinsic molecular characteristics of tumors correlate with distinct imaging subgroups in pLGG, paving the way for future multimodal investigations that may enhance understanding of disease progression and targetability.

Indexed as

Brain NeoplasmsGliomaAdolescentChildChild, PreschoolCluster AnalysisFemaleHumansInfantMaleMutationNeoplasm GradingProto-Oncogene Proteins B-rafTranscriptomeProto-Oncogene Proteins B-raf

Identifiers

PMID39952665
PMCPMC12453517

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.