Evidence map›Paper›PMID 39952663›Full record

ArticleAJNR. American journal of neuroradiology2025

Impact of Stenosis Degree on Outcomes of Stent Placement versus Medical Treatment Alone for Symptomatic Intracranial Stenosis: A Pooled Individual Patient Data Analysis.

Zixuan Xing, Tianhua Li, Eyad Almallouhi, Peng Gao, Jichang Luo, Haozhi Gong, Xuesong Bai, Colin P Derdeyn, Tao Wang, Liqun Jiao and 1 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zixuan XingFrom the Department of Neurosurgery (Z.X., T.L., P.G., J.L., H.G., X.B., T.W., L.J.), Xuanwu Hospital, China International Neuroscience Institute, Capital Medical University, National Center for Neurological Disorders, Beijing, China.ORCID https://orcid.org/0000-0001-7935-2575
Tianhua LiFrom the Department of Neurosurgery (Z.X., T.L., P.G., J.L., H.G., X.B., T.W., L.J.), Xuanwu Hospital, China International Neuroscience Institute, Capital Medical University, National Center for Neurological Disorders, Beijing, China.
Eyad AlmallouhiNeuro Interventional Surgery (E.A.), Sarasota Memorial Hospital, Sarasota, Florida, USA.
Peng GaoFrom the Department of Neurosurgery (Z.X., T.L., P.G., J.L., H.G., X.B., T.W., L.J.), Xuanwu Hospital, China International Neuroscience Institute, Capital Medical University, National Center for Neurological Disorders, Beijing, China.
Jichang LuoFrom the Department of Neurosurgery (Z.X., T.L., P.G., J.L., H.G., X.B., T.W., L.J.), Xuanwu Hospital, China International Neuroscience Institute, Capital Medical University, National Center for Neurological Disorders, Beijing, China.ORCID https://orcid.org/0000-0002-8341-0966
Haozhi GongFrom the Department of Neurosurgery (Z.X., T.L., P.G., J.L., H.G., X.B., T.W., L.J.), Xuanwu Hospital, China International Neuroscience Institute, Capital Medical University, National Center for Neurological Disorders, Beijing, China.
Xuesong BaiFrom the Department of Neurosurgery (Z.X., T.L., P.G., J.L., H.G., X.B., T.W., L.J.), Xuanwu Hospital, China International Neuroscience Institute, Capital Medical University, National Center for Neurological Disorders, Beijing, China.ORCID https://orcid.org/0000-0003-4324-1181
Colin P DerdeynDepartment of Radiology and Medical Imaging (C.P.D.), University of Virginia, Charlottesville, Virginia, USA.
Tao WangFrom the Department of Neurosurgery (Z.X., T.L., P.G., J.L., H.G., X.B., T.W., L.J.), Xuanwu Hospital, China International Neuroscience Institute, Capital Medical University, National Center for Neurological Disorders, Beijing, China.
Liqun JiaoFrom the Department of Neurosurgery (Z.X., T.L., P.G., J.L., H.G., X.B., T.W., L.J.), Xuanwu Hospital, China International Neuroscience Institute, Capital Medical University, National Center for Neurological Disorders, Beijing, China liqunjiao@sina.cn.ORCID https://orcid.org/0000-0003-4982-6295
6S Collaborators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeWhether differences in stenosis degree affect treatment selection in patients with intracranial artery atherosclerotic stenosis (ICAS) still remains unclear. This study explores the impact of stenosis degree on outcomes of stent placement compared with medical therapy alone in patients with symptomatic intracranial artery stenosis. MATERIALS AND

methodsPatients with a TIA or nondisabling ischemic stroke, attributed to 70%-99% stenosis of a major intracranial artery, were included. The patient cohort was drawn from the China Angioplasty and Stenting for Symptomatic Intracranial Severe Stenosis and the Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis trials. The primary outcome was a composite of stroke or death within 30 days or stroke in the qualifying artery territory beyond 30 days through 1 year.

resultsOf 806 patients, 92 patients (11%) met the primary outcome. As the degree of stenosis increased, the risk of the primary end point was significantly lower in the stent placement group (

conclusionsPatients with higher degrees of stenosis are more likely to benefit from stent placement. Patients with intracranial artery stenosis exceeding 85% may be the focus of future studies. If innovations in interventional techniques significantly reduce perioperative risk, the critical threshold of 85% as the degree of stenosis might be reconsidered.

Indexed as

Intracranial ArteriosclerosisStentsAgedConstriction, PathologicFemaleHumansMaleMiddle AgedTreatment Outcome

Identifiers

PMID39952663
PMCPMC12453498

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.