Evidence map›Paper›PMID 39952630›Full record

Trial reportClinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery2025

Comparison of White Light With Narrow Band Imaging Using Flexible Laryngoscopy for the Detection of Local Recurrences After (Chemo)Radiation for Pharyngeal or Laryngeal Cancer: A Randomised Controlled Trial.

Constanze Scholman, Jeroen M Westra, Manon A Zwakenberg, Jan Wedman, Bert van der Vegt, Roel J H M Steenbakkers, Sjoukje F Oosting, Gyorgy B Halmos, Bernard F A M van der Laan, Boudewijn E C Plaat

Abstract readRandomized Controlled TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Constanze ScholmanDepartment of Otorhinolaryngology - Head & Neck Surgery, University of Groningen, University of Medical Center Groningen, Groningen, the Netherlands.ORCID 0000-0001-8717-0472
Jeroen M WestraDepartment of Otorhinolaryngology - Head & Neck Surgery, University of Groningen, University of Medical Center Groningen, Groningen, the Netherlands.ORCID 0000-0002-1793-0648
Manon A ZwakenbergDepartment of Otorhinolaryngology - Head & Neck Surgery, University of Groningen, University of Medical Center Groningen, Groningen, the Netherlands.ORCID 0000-0002-6825-7932
Jan WedmanDepartment of Otorhinolaryngology - Head & Neck Surgery, University of Groningen, University of Medical Center Groningen, Groningen, the Netherlands.ORCID 0000-0001-6448-134X
Bert van der VegtDepartment of Pathology and Medical Biology, University of Groningen, University of Medical Center Groningen, Groningen, the Netherlands.ORCID 0000-0002-2613-1506
Roel J H M SteenbakkersDepartment of Radiation Oncology, University of Groningen, University of Medical Center Groningen, Groningen, the Netherlands.
Sjoukje F OostingDepartment of Medical Oncology, University of Groningen, University of Medical Center Groningen, Groningen, the Netherlands.
Gyorgy B HalmosDepartment of Otorhinolaryngology - Head & Neck Surgery, University of Groningen, University of Medical Center Groningen, Groningen, the Netherlands.ORCID 0000-0003-2460-2260
Bernard F A M van der LaanDepartment of Otorhinolaryngology - Head & Neck Surgery, University of Groningen, University of Medical Center Groningen, Groningen, the Netherlands.
Boudewijn E C PlaatDepartment of Otorhinolaryngology - Head & Neck Surgery, University of Groningen, University of Medical Center Groningen, Groningen, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesEarly detection of local recurrences in patients with head and neck squamous cell carcinoma (HNSCC) is crucial for long-term survival. Aim of this study was to compare white light (WL) imaging with narrow band imaging (NBI) during flexible laryngoscopy for detection of local recurrences and evaluate the effects on clinical outcome in patients with HNSCC treated with radiotherapy ± chemotherapy ((C)RT).

designProspective randomised controlled trial.

settingTertiary head and neck oncologic center.

participants257 patients without residual disease after (C)RT were randomised in a WL group (n = 120) or WL-NBI group (n = 137) and followed for 24 months.

main outcome measuresLocal recurrence rate and overall survival, disease-specific survival, disease-free survival and local recurrence-free survival were compared between both groups.

resultsDetection rate of local recurrences was the same in both groups: 11.7% in WL-NBI and 10.0% in WL (p > 0.05). Overall survival (WL: 88.3%, WL-NBI: 87.6%), disease-specific survival (WL: 86.7%, NBI: 83.9%), disease-free survival (WL: 85.0%, WL-NBI: 83.2%) and local recurrence-free survival (WL: 90.0%, WL-NBI: 89.1%) showed no superiority in the WL-NBI group (p > 0.05).

conclusionsLocal recurrence rates are relatively low in the first 24 months after (C)RT for HNSCC. WL-NBI did not improve the detection of local recurrences nor the survival compared to WL.

trial registrationThis randomised clinical trial was registered at the research register UMCG with the number 201500918.

Indexed as

Carcinoma, Squamous CellLaryngeal NeoplasmsLaryngoscopyLightNarrow Band ImagingNeoplasm Recurrence, LocalPharyngeal NeoplasmsAdultAgedChemoradiotherapyFemaleHumansMaleMiddle AgedProspective Studiesclinical outcomeflexible laryngoscopyhead and neck cancernarrow band imagingrandomised controlled trialrecurrence

Identifiers

PMID39952630
PMCPMC12128008

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.