Evidence map›Paper›PMID 39952566›Full record

ArticleJournal of lipid research2025

Liver specific transgenic expression of CYP7B1 attenuates early western diet-induced MASLD progression.

Genta Kakiyama, Nanah Bai-Kamara, Daniel Rodriguez-Agudo, Hajime Takei, Kei Minowa, Michael Fuchs, Sudha Biddinger, Jolene J Windle, Mark A Subler, Tsuyoshi Murai and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of lipid research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Genta KakiyamaDepartment of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA, USA; Research Services, Central Virginia Veterans Affairs Health Care System, Richmond, VA, USA. Electronic address: genta.kakiyama@vcuhealth.org.
Nanah Bai-KamaraResearch Services, Central Virginia Veterans Affairs Health Care System, Richmond, VA, USA.
Daniel Rodriguez-AgudoDepartment of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA, USA; Research Services, Central Virginia Veterans Affairs Health Care System, Richmond, VA, USA.
Hajime TakeiJunshin Clinic Bile Acid Institute, Meguro-ku, Tokyo, Japan.
Kei MinowaDepartment of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA, USA; Research Services, Central Virginia Veterans Affairs Health Care System, Richmond, VA, USA; Department of Pediatrics, Juntendo University Faculty of Medicine, Bunkyo-ku, Tokyo, Japan.
Michael FuchsDepartment of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA, USA; Research Services, Central Virginia Veterans Affairs Health Care System, Richmond, VA, USA.
Sudha BiddingerDivision of Endocrinology, Boston Children's Hospital, Harvard Medical School, MA, USA.
Jolene J WindleDepartment of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond VA, USA.
Mark A SublerDepartment of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond VA, USA.
Tsuyoshi MuraiSchool of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari, Hokkaido, Japan.
Mitsuyoshi SuzukiDepartment of Pediatrics, Juntendo University Faculty of Medicine, Bunkyo-ku, Tokyo, Japan.
Hiroshi NittonoJunshin Clinic Bile Acid Institute, Meguro-ku, Tokyo, Japan.
Arun SanyalDepartment of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA, USA; Stravitz-Sanyal Institute for Liver Disease and Metabolic Health, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
William M PandakDepartment of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA, USA; Research Services, Central Virginia Veterans Affairs Health Care System, Richmond, VA, USA.

Funding

Virus Vector Shared ResourceP30CA016059 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Keri R Maher · 1985 to 2026
$51.0M
Novel Targets for Reducing Atherosclerosis in Type 1 DiabetesR01HL161092 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI BIDDINGER, SUDHA B · 2022 to 2025
$2.7M
BLRD VA I01 BX000197BLRD VA I01 BX005895NCI NIH HHS P30 CA016059NHLBI NIH HHS R01 HL161092NIDDK NIH HHS L40 DK065607
6 · The paper itself

Abstract

Effect of liver specific oxysterol 7α-hydroxylase (CYP7B1) overexpression on the Western diet (WD)-induced metabolic dysfunction-associated steatotic liver disease (MASLD) progression was studied in mice. Among various hepatic genes impacted during MASLD development, CYP7B1 is consistently suppressed in multiple MASLD mouse models and in human MASLD cohorts. CYP7B1 enzyme suppression leads to accumulations of bioactive oxysterols such as (25R)26-hydroxycholesterol (26HC) and 25-hydroxycholesterol (25HC). We challenged liver specific CYP7B1 transgenic (CYP7B1

Indexed as

25-Hydroxyvitamin D3 1-alpha-HydroxylaseCytochrome P450 Family 7Diet, WesternDisease ProgressionFatty LiverLiverAnimalsHumansMaleMiceMice, TransgenicSteroid Hydroxylases25-Hydroxyvitamin D3 1-alpha-HydroxylaseCyp7b1 protein, mouseCytochrome P450 Family 7Steroid HydroxylasesCD36cholesterolinflammationlipotoxicitylivermitochondriaoxysterol

Identifiers

PMID39952566
PMCPMC11954105

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.