ArticleThe Journal of infection2025
Increasing child vaccination coverage can reduce influenza cases across age groups: An agent-based modeling study.
Article in The Journal of infection, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Expert opinion on improving influenza vaccination coverage rate in Qatar: Strategic solutions and role of live attenuated influenza vaccine (LAIV).Human vaccines & immunotherapeutics · 2026Review
- Higher Pediatric Influenza Vaccination Coverage in Pooled Northern Hemisphere Countries with Public Access to Live Attenuated Influenza Vaccine: Implications for Immunization Policy.Infectious diseases and therapy · 2026Article
- Live Attenuated Influenza Vaccine (LAIV) for Children for the Prevention of Influenza Illness in Sweden: A Cost-Effectiveness Analysis.Infectious diseases and therapy · 2026Article
- Parent-Reported Influenza Vaccination Uptake, Hesitancy and Willingness for In-School Children: Survey Findings From Shenzhen, China With Free Vaccination Services.Tropical medicine & international health : TM & IH · 2026Article
- Post-COVID-19 Burden of Severe Influenza in England Among Overall Population and High-Risk Groups: Results From the INFORM Study, 2022-2023.Infectious diseases and therapy · 2026Article
- Simulating targeted vaccination strategies with network-based and agent-based models: A scoping review.PLOS global public health · 2026Article
- Article
- Development of a broad-spectrum nasal live attenuated influenza vaccine based on mosaic antigen design against influenza B viruses.Emerging microbes & infections · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectivesAvailability of caregiver-administered nasal spray live attenuated influenza vaccine (LAIV) raises the potential for increased influenza vaccine uptake. Direct and indirect benefits (decreased influenza cases and hospitalizations) of increased uptake among school-age children may be realized across the age spectrum. We used an agent-based model to determine the extent to which increased vaccination of children might affect overall influenza epidemiology.
methodsThe Framework for Reproducing Epidemiological Dynamics (FRED) uses a population based on the US census and accounts for individual characteristics to estimate the effect of changes in parameters including vaccine uptake, on outcomes. We modeled increases in vaccine uptake among school-age children 5-17 years old on influenza cases and hospitalizations by age group.
resultsIncreasing vaccination rates in school-aged children by 5%-15% decreased their symptomatic influenza cases by 3.2%-10.9%, and among all age groups by 3.3%-11.6%, corresponding to an estimated annual reduction in cases of 522,867-1,810,170 among school-age children and of 1,394,687-4,945,952 overall. Annual U.S. hospitalizations could decrease by as much as 49,977, with the greatest impact (23,258) in those ages 65 years and over.
conclusionsThe opportunity to increase vaccination coverage in school-age children using LAIV can have a positive impact across all ages.
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