Evidence map›Paper›PMID 39952365›Full record

ArticleTransplantation and cellular therapy2025

Pediatric Transplant and Cellular Therapy Consortium RESILIENT Conference on Pediatric Chronic Graft-versus-Host Disease Survivorship after Hematopoietic Cell Transplantation: Part III. Long-Term Impact of Chronic Graft-versus-Host Disease on Endocrinologic, Cardiovascular, and Metabolic Outcomes in Survivors of Pediatric Hematopoietic Cell Transplantation.

Pooja Khandelwal, Jonathan D Fish, Lev Gorfinkel, Gregory M T Guilcher, Jonathan Howell, Miki Nishitani, Brandon Nuechterlein, Esther Obeng, Ami J Shah, Geoffrey D E Cuvelier and 3 more

Abstract read
In one paragraph

Article in Transplantation and cellular therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Optimizing Haploidentical Donor Selection for Pediatric Hematopoietic Cell Transplant.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2026
    Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Pooja KhandelwalCincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Jonathan D FishSteven and Alexandra Cohen Children's Medical Center, Queens, New York.
Lev GorfinkelDana-Farber Cancer Institute, Boston, Massachusetts.
Gregory M T GuilcherUniversity of Calgary Medical Centre, Calgary, Alberta, Canada.
Jonathan HowellCincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Miki NishitaniDana-Farber Cancer Institute, Boston, Massachusetts.
Brandon NuechterleinUniversity of Colorado Anschutz Medical Campus School of Medicine, Aurora, Colorado.
Esther ObengSaint Jude Children's Research Hospital Memphis, Tennessee.
Ami J ShahStanford University School of Medicine, Stanford, California.
Geoffrey D E CuvelierAlberta Children's Hospital, Calgary, Alberta, Canada.
Seth RotzCleveland Clinic, Cleveland, Ohio.
Kirsten M WilliamsChildren's Healthcare of Atlanta, Atlanta, Georgia.
Christine N DuncanDana-Farber Cancer Institute, Boston, Massachusetts. Electronic address: christine_duncan@dfci.harvard.edu.

Funding

Research and Education towards Solutions for Late effects to Innovate, Excel, and Nurture after chronic Graft-versus-Host Disease (RESILIENT after cGVHD)R13HL172559 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI ROTZ, SETH J · 2024 to 2024
$37k
NHLBI NIH HHS R13 HL172559
6 · The paper itself

Abstract

Chronic graft-versus-host disease (cGVHD) has a profound impact on the endocrinologic and cardiovascular health of survivors of transplantation performed in childhood. The impact of cGVHD is long-lasting and contributes to morbidity and early mortality through multiple mechanisms. Organs and tissues may be direct targets of alloreactive donor-derived immune cells. Corticosteroids and other cGVHD-directed therapies influence hormonal actions, alter bone metabolism, and negatively impact cardiometabolic health. Pediatric survivors are particularly vulnerable to the endocrinologic and cardiovascular effects of cGVHD as it develops during periods of intense growth and development, although little is known about the direct contribution to late effects. The Research and Education Toward Solutions for Late Effects to Innovate, Excel, and Nurture after cGVHD (RESILIENT after cGVHD) effort brought together content experts to determine the state of the science, develop clinical recommendations, and propose a research agenda in endocrine, cardiovascular, and metabolic cGVHD survivorship, which are detailed in this report.

Indexed as

Cardiovascular DiseasesEndocrine System DiseasesGraft vs Host DiseaseHematopoietic Stem Cell TransplantationChildChronic DiseaseHumansSurvivorsCardiacCardiovascularChildrenEndocrineGraft-versus-host diseaseGVHDHSCTPediatricSkeletal

Identifiers

PMID39952365
PMCPMC12082646

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.