ArticleDrug and alcohol dependence2025
Ecological momentary assessment study of same-hour polysubstance use among people who use opioids and additional substances.
Article in Drug and alcohol dependence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Daily patterns of opioid and stimulant use and associated risk-behavior outcomes: A cohort study.Addictive behaviors · 2026Article
- Smartphone-Based Ecological Momentary Assessment to Monitor Opioid Use and Overdose Among People Who Use Opioids: Prospective Observational Feasibility Study.JMIR human factors · 2026Observational
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundPolysubstance use is a defining feature of the opioid overdose epidemic in the United States today. Most quantitative studies of polysubstance use rely on 30-day retrospective measures. Understanding how drugs are co-used in shorter (daily and hourly) timeframes enhances our understanding of polysubstance-related overdose risk.
methodsWe used ecological momentary assessment (EMA) to assess polysubstance in community-based sample of people who use drugs in Oakland, CA (N = 117). Participants provided data on substance use three times daily over 28 days, using a smartphone app. We created binary variables of same-day and same-hour polysubstance use and estimated its prevalence with mixed-effects logistic regression models.
resultsThe response rate to thrice-daily prompts was 64.6 %. The prevalence of same-day polysubstance use on any given day was 0.77 (95 % CI 0.73, 0.82), and the prevalence of same-hour polysubstance use was 0.71 (95 % CI 0.66, 0.76). Defined as the combination of opioids with stimulants, opioids with alcohol, opioids with benzodiazepines, or more than one opioid in the same hour, the probability of risky polysubstance use on a given day was 0.59 (95 % CI 0.52, 0.65). Excluding methadone from a treatment program, the probability of risky polysubstance use on a given day was 0.51 (95 % CI 0.44, 0.58).
conclusionsOur findings highlight the importance of targeted prevention efforts addressing the diverse substance combinations that increase overdose risk. It is crucial to develop and test substance use treatment and overdose prevention strategies that address the complexities of polysubstance use, in partnership with people who use drugs.
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