ArticleNeurology2025
Montreal Cognitive Assessment vs the Mini-Mental State Examination as a Screening Tool for Patients With Genetic Frontotemporal Dementia.
Article in Neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Chinese medicine interventions for cerebral small vessel disease-related cognitive impairment: a systematic review and meta-analysis.Frontiers in pharmacology · 2026Pooled it
- Psychic and Cognitive Impacts of Cardiovascular Disease: Evidence from an Observational Study and Comparison by a Systematic Literature Review.Medical sciences (Basel, Switzerland) · 2025Pooled it
- Cognitive Screening of Federal Public Leaders: MoCA Performance, Cognitive Risk, and Predictors of Variability in a Highly Educated Workforce.Scandinavian journal of psychology · 2026Article
- Validity of the T-MoCA for Screening MCI and Dementia and Its Equivalence to the K-MoCA-22.Journal of Korean medical science · 2026Article
- Cognitive Function Mediates the Association Between Type 2 Diabetes and Physical Performance Decline in Older Adults: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- Outer nuclear layer thinning as an in vivo biomarker for discriminating probable FTLD-tau from probable FTLD-TDP with PET-supported subtyping.Alzheimer's research & therapy · 2026Article
- Surface-based cortical thickness and gyrification mapping with data-driven prediction of cognitive impairment in prediabetes.IBRO neuroscience reports · 2026Article
- White Matter Hyperintensities and Clinical Phenotype in Late-Onset Psychiatric Disorders: A Multidimensional Clinical-Neuroimaging Study.Neurology international · 2026Article
- Limited Diagnostic Performance of Cerebrospinal Fluid Glial Fibrillary Acidic Protein in Dementia.Dementia and geriatric cognitive disorders · 2026Article
- Study on the effectiveness and safety of balance instrument training on balance and lower limb motor function in patients with ischemic stroke hemiplegia.Frontiers in rehabilitation sciences · 2026Article
- Number of natural teeth and intrinsic capacity among hospitalized older adults in China: a cross-sectional study on the role of social support.Frontiers in medicine · 2026Article
- Association of Intracranial Plaque Features with the Severity of White Matter Hyperintensities in Middle-Aged and Older Community-Dwelling Adults.Biomedicines · 2025Article
- Functional Impairment in Behavioral Variant Frontotemporal Dementia: Cognitive, Behavioral, Personality, and Brain Perfusion Contributions.Journal of personalized medicine · 2025Article
- Cognitive function and dementia risk factors among older people in nursing homes: An observational cohort study in Medan, Indonesia.Belitung nursing journal · 2025Article
- Review
- Design and baseline findings of the NEODEM prospective cohort on early-onset neurodegenerative dementia.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesWith upcoming clinical trials targeting preclinical stages of genetic frontotemporal dementia (FTD), early detection through cognitive screening is crucial. The Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) have potential as screening instruments for early-stage genetic FTD. However, no comparative evaluation has been performed. We aimed to compare MMSE and MoCA performance among presymptomatic, prodromal, and symptomatic pathogenic variant carriers to analyze which screening test has superior discriminative abilities.
methodsWe used cross-sectional and longitudinal data from 2 longitudinal genetic FTD cohort studies in the Netherlands and the United Kingdom, collected between 2021 and 2024. Participants were either presymptomatic, prodromal, or symptomatic pathogenic variant carriers or healthy controls (first-degree family members without pathogenic variants for FTD). Grouping was based on the global CDR-plus-NACC-FTLD score. Participants were assessed with both MoCA and MMSE. Statistical analyses compared total and subscores between groups and evaluated predictive and classification accuracy of both tests.
resultsA total of 243 participants (mean age 49.9 ± 13.1 years, mean education 14.5 ± 3.0 years, 56% female), 157 of whom were pathogenic variant carriers ( DISCUSSION: Its higher sensitivity and better discriminative power make MoCA a more valuable tool for cognitive screening in upcoming clinical trials targeting preclinical FTD. Future studies should aim for larger sample sizes from additional study centers.
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