Evidence map›Paper›PMID 39951544›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2025

Associations of physical activity and sedentary time with aortic stiffness and autonomic function in early pregnancy.

Virginia R Nuckols, Kristen G Davis, Gary L Pierce, Bethany Barone Gibbs, Kara M Whitaker

Registry-linked trialAbstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04749849 (Sedentary Behavior, Physical Activity, Sleep, and Cardiovascular Risk in Pregnancy), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04749849 completednot on this map

Sedentary Behavior, Physical Activity, Sleep, and Cardiovascular Risk in Pregnancy: the Pregnancy 24/7 Cohort Study

TypeobservationalSponsorKara WhitakerRan2021 to 2025Enrolled500ConditionsHealthy
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Virginia R NuckolsDepartment of Health and Human Physiology, The University of Iowa, Iowa City, Iowa, United States.ORCID 0000-0001-5879-5991
Kristen G DavisDepartment of Health and Human Physiology, The University of Iowa, Iowa City, Iowa, United States.ORCID 0009-0009-0372-207X
Gary L PierceDepartment of Health and Human Physiology, The University of Iowa, Iowa City, Iowa, United States.ORCID 0000-0001-7499-080X
Bethany Barone GibbsDepartment of Epidemiology and Biostatistics, West Virginia University, Morgantown, West Virginia, United States.
Kara M WhitakerDepartment of Health and Human Physiology, The University of Iowa, Iowa City, Iowa, United States.ORCID 0000-0003-2343-4162

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
Sedentary behavior, physical activity, sleep, and cardiovascular risk in pregnancy: the Pregnancy 24/7 cohort studyR01HL153095 · NHLBI · UNIVERSITY OF IOWA · PI WHITAKER, KARA MARIE · 2020 to 2024
$3.6M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01-HL153095NHLBI NIH HHS R01 HL153095NIEHS NIH HHS P30 ES005605Russell B. Day and Florence D. Day Endowed Chair in Liberal Arts and Sciences at the University of IowaUniversity of Iowa Graduate College Diversity FellowshipUniversity of Iowa Graduate College Summer Fellowship
6 · The paper itself

Abstract

Rapid cardiovascular and autonomic adaptations occur during early pregnancy to accommodate augmented cardiac output and placental circulation, with inadequate adaptation associated with hypertensive pregnancy complications. Habitual physical activity (PA) and limiting time in sedentary behavior (SED) may improve pregnancy-related vascular and autonomic function. The objective of this study was to examine the magnitude of the predicted associations between device-measured PA and SED with cardiovascular and autonomic biomarkers including aortic stiffness, blood pressure variability (BPV), and baroreflex sensitivity (BRS) in the first trimester of pregnancy. Pregnant women (

Indexed as

Autonomic Nervous SystemExerciseSedentary BehaviorVascular StiffnessAdultBaroreflexBlood PressureFemaleHeart RateHumansPregnancyPregnancy Trimester, FirstPulse Wave AnalysisYoung Adultaortic stiffnessbaroreflexblood pressure variability

Identifiers

PMID39951544
PMCPMC12305502

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.