Evidence map›Paper›PMID 39951523›Full record

ArticleScience advances2025

Distinct input-specific mechanisms enable presynaptic homeostatic plasticity.

Chun Chien, Kaikai He, Sarah Perry, Elizabeth Tchitchkan, Yifu Han, Xiling Li, Dion Dickman

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Temporal and Cell-Specific Regulation of Synaptic Homeostasis by the Chromatin Remodeler Chd1.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Article
  4. Article
  5. Nonionic signaling rapidly remodels postsynaptic DLG to induce retrograde homeostatic plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Monoamine-induced diacylglycerol signaling rapidly accumulates Unc13 in nanoclusters for fast presynaptic potentiation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Deficiency in transmitter release triggers homeostatic transcriptional changes that increase presynaptic excitability.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Review
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Chun ChienDepartment of Neurobiology, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0003-0132-8457
Kaikai HeDepartment of Neurobiology, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0003-2002-4862
Sarah PerryDepartment of Neurobiology, University of Southern California, Los Angeles, CA, USA.
Elizabeth TchitchkanDepartment of Neurobiology, University of Southern California, Los Angeles, CA, USA.ORCID 0009-0006-4664-9296
Yifu HanDepartment of Neurobiology, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-1201-654X
Xiling LiDepartment of Neurobiology, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-2727-244X
Dion DickmanDepartment of Neurobiology, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0003-1884-284X

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Molecular Mechanisms Governing the Homeostatic Control of Synaptic StrengthR01NS091546 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DICKMAN, DION KAI · 2015 to 2024
$4.3M
Generating functional diversity from molecular homogeneity at glutamatergic synapsesR01NS126654 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DION KAI DICKMAN · 2023 to 2026
$1.8M
NIH HHS P40 OD018537NINDS NIH HHS R01 NS091546NINDS NIH HHS R01 NS126654
6 · The paper itself

Abstract

Synapses are endowed with the flexibility to change through experience, but must be sufficiently stable to last a lifetime. This tension is illustrated at the

Indexed as

HomeostasisNeuromuscular JunctionNeuronal PlasticityPresynaptic TerminalsAnimalsCalciumDrosophilaDrosophila melanogasterGlutamic AcidMotor NeuronsReceptors, GlutamateSynapsesSynaptic TransmissionCalciumGlutamic AcidReceptors, Glutamate

Identifiers

PMID39951523
PMCPMC11827636

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.