ArticleProceedings of the National Academy of Sciences of the United States of America2025
AI protocol for retrieving protein dynamic structures from two-dimensional infrared spectra.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Multidimensional Infrared Spectroscopy as a Bioanalytical Technique.Chemical reviews · 2026Review
- Exploiting correlations in multi-coincidence Coulomb explosion patterns for differentiating molecular structures using machine learning.Nature communications · 2025Article
- Generation of protein dynamics by machine learning.Current opinion in structural biology · 2025Review
- AI protocol for retrieving protein dynamic structures from two-dimensional infrared spectra.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
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10 authors.
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Abstract
Understanding the dynamic evolution of protein structures is crucial for uncovering their biological functions. Yet, real-time prediction of these dynamic structures remains a significant challenge. Two-dimensional infrared (2DIR) spectroscopy is a powerful tool for analyzing protein dynamics. However, translating its complex, low-dimensional signals into detailed three-dimensional structures is a daunting task. In this study, we introduce a machine learning-based approach that accurately predicts dynamic three-dimensional protein structures from 2DIR descriptors. Our method establishes a robust "spectrum-structure" relationship, enabling the recovery of three-dimensional structures across a wide variety of proteins. It demonstrates broad applicability in predicting dynamic structures along different protein folding trajectories, spanning timescales from microseconds to milliseconds. This approach also shows promise in identifying the structures of previously uncharacterized proteins based solely on their spectral descriptors. The integration of AI with 2DIR spectroscopy offers insights and represents a significant advancement in the real-time analysis of dynamic protein structures.
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