Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
14 authors.
Hala K HaddadDivision of Biology and Medicine, Department of Neuroscience, Brown University, Providence, RI 02912.ORCID 0000-0001-7033-7280
Jonathan I Mercado-ReyesDivision of Pediatric Ophthalmology, Abrahamson Pediatric Eye Institute, and Science of Light Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.ORCID 0000-0002-5480-7681
E Román MustafáElectrophysiology Lab, Instituto Multidisciplinario de Biología Celular, La Plata, Buenos Aires 1900, Argentina.
Shane P D'SouzaDivision of Pediatric Ophthalmology, Abrahamson Pediatric Eye Institute, and Science of Light Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.ORCID 0000-0001-6344-1434
C Sean ChungDivision of Biology and Medicine, Department of Neuroscience, Brown University, Providence, RI 02912.
Ramses R M NestorDivision of Biology and Medicine, Department of Neuroscience, Brown University, Providence, RI 02912.ORCID 0009-0009-0564-7990
Lauren E OlinskiDivision of Biology and Medicine, Department of Neuroscience, Brown University, Providence, RI 02912.
Valentina Martinez DamonteDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305.
Joshua SaskinDivision of Biology and Medicine, Department of Neuroscience, Brown University, Providence, RI 02912.ORCID 0000-0001-5372-9696
Shruti VemarajuDivision of Pediatric Ophthalmology, Abrahamson Pediatric Eye Institute, and Science of Light Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.ORCID 0000-0001-6698-6253
Jesica RaingoElectrophysiology Lab, Instituto Multidisciplinario de Biología Celular, La Plata, Buenos Aires 1900, Argentina.ORCID 0000-0002-2307-0373
Julie A KauerDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0002-3362-1642
Richard A LangDivision of Pediatric Ophthalmology, Abrahamson Pediatric Eye Institute, and Science of Light Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.ORCID 0000-0002-5212-254X
Elena OanceaDivision of Biology and Medicine, Department of Neuroscience, Brown University, Providence, RI 02912.ORCID 0000-0001-9584-5230
Funding
Genetic and molecular basis for variation in human skin pigmentationR01AR076241 · NIAMS · CHILDREN'S HOSP OF PHILADELPHIA · PI MARKS, MICHAEL S, OANCEA, ELENA · 2020 to 2024
$5.5M
Dopamine Mediated Control of Retinal Vascular IntegrityR01EY032566 · NEI · BAYLOR COLLEGE OF MEDICINE · PI Melanie A Samuel · 2022 to 2026
$3.1M
Regulation of vascular development in the eye by an opsin 5-dependent clockR01EY027077 · NEI · CINCINNATI CHILDRENS HOSP MED CTR · PI LANG, RICHARD A., RAO, SUJATA · 2016 to 2020
$2.4M
Light regulated vascular development in the eye via the Hippo pathwayR01EY032029 · NEI · CINCINNATI CHILDRENS HOSP MED CTR · PI LANG, RICHARD A., XIN, MEI · 2021 to 2024
$1.6M
Mechanisms of intrinsic light responses in the ocular lensR01EY032752 · NEI · CINCINNATI CHILDRENS HOSP MED CTR · PI LANG, RICHARD A. · 2021 to 2024
$1.6M
Melanopsin-dependent light-evoked development of rod photoreceptorsR01EY034456 · NEI · CINCINNATI CHILDRENS HOSP MED CTR · PI Richard A. Lang · 2023 to 2026
$1.5M
Brown University (BU) Carney Graduate FellowshipCincinnati Children's Hospital Medical Center (CCHMC) oldman Chair of the Abrahamson Pediatric Eye InstituteHHS | NIH | National Eye Institute (NEI) R01EY027077HHS | NIH | National Eye Institute (NEI) R01EY032029HHS | NIH | National Eye Institute (NEI) R01EY032566HHS | NIH | National Eye Institute (NEI) R01EY032752HHS | NIH | National Eye Institute (NEI) R01EY034456HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) R01AR076241NEI NIH HHS R01 EY027077NEI NIH HHS R01 EY032029NEI NIH HHS R01 EY032566NEI NIH HHS R01 EY032752NEI NIH HHS R01 EY034456NIAMS NIH HHS R01 AR076241NSF | NSF Graduate Research Fellowship Program (GRFP) GRFP
6 · The paper itself
Abstract
Mammalian opsin 3 (OPN3) is a member of the opsin family of G-protein-coupled receptors with ambiguous light sensitivity. OPN3 was first identified in the brain (and named encephalopsin) and subsequently found to be expressed in other tissues. In adipocytes, OPN3 is necessary for light responses that modulate lipolysis and glucose uptake, while OPN3 in human skin melanocytes regulates pigmentation in a light-independent manner. Despite its initial discovery in the brain, OPN3 functional mechanisms in the brain remain elusive. Here, we investigated the molecular mechanism of OPN3 function in the paraventricular nucleus (PVN) of the hypothalamus. We show that
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Hypothalamic opsin 3 suppresses MC4R signaling and potentiates Kir7.1 to promote food consumption. · full record | OpenQuestion