Evidence map›Paper›PMID 39951378›Full record

ArticleCell reports2025

Astrocyte Kir4.1 expression level territorially controls excitatory transmission in the brain.

Olga Tyurikova, Olga Kopach, Kaiyu Zheng, Daman Rathore, Neela Codadu, Sheng-Yi Wu, Yi Shen, Robert E Campbell, Rob C Wykes, Kirill Volynski and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Astrocytic KFrontiers in aging neuroscience · 2026
    Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Astrocyte gap junctions and KFrontiers in cellular neuroscience · 2025
    Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Olga TyurikovaDepartment of Clinical & Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK. Electronic address: olga.tyurikova.15@ucl.ac.uk.
Olga KopachDepartment of Clinical & Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK; Neuroscience and Cell Biology Research Institute, City St George's, University of London, Cranmer Terrace, London SW17 0RE, UK.
Kaiyu ZhengDepartment of Clinical & Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Daman RathoreDepartment of Clinical & Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Neela CodaduDepartment of Clinical & Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Sheng-Yi WuDepartment of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada.
Yi ShenDepartment of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada.
Robert E CampbellDepartment of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada; Department of Chemistry, Graduate School of Science, The University of Tokyo, Tokyo 113-0033, Japan.
Rob C WykesDepartment of Clinical & Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK; Division of Neuroscience & Centre for Nanotechnology in Medicine, The University of Manchester, Manchester M13 9PL, UK.
Kirill VolynskiDepartment of Clinical & Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Leonid P SavtchenkoDepartment of Clinical & Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Dmitri A RusakovDepartment of Clinical & Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK. Electronic address: d.rusakov@ucl.ac.uk.

Funding

Medical Research Council MR/W019752/1National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/X001067/1Wellcome Trust 223131
6 · The paper itself

Abstract

Intense brain activity elevates extracellular potassium, potentially leading to overexcitation and seizures. Astrocytes are crucial for restoring healthy potassium levels, and an emerging focus on their Kir4.1 channels has reopened the quest into the underlying mechanisms. We find that the Kir4.1 level in individual astrocytes sets the kinetics of their potassium and glutamate uptake current. Combining electrophysiology with multiplexed optical sensor imaging and FLIM reveals that rises in extracellular potassium would normally boost presynaptic Ca

Indexed as

AstrocytesBrainPotassium Channels, Inwardly RectifyingSynaptic TransmissionAnimalsCalciumGlutamic AcidKcnj10 ChannelMicePotassiumSynapsesCalciumGlutamic AcidKcnj10 ChannelPotassiumPotassium Channels, Inwardly Rectifyingastrocyteastrocyte modelCP: NeuroscienceFLIMglutamate sensorhippocampusKir4.1 channelspotassium bufferingpotassium homeostasisrelease probabilitysynapse

Identifiers

PMID39951378
PMCPMC7618397

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.