Evidence map›Paper›PMID 39951351›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Electret-Inspired Charge-Injected Hydrogel for Scar-Free Healing of Bacterially Infected Burns Through Bioelectrical Stimulation and Immune Modulation.

Mujie Liu, Yuheng Wang, Haodong Wang, Lihong Qi, Yuxuan Shang, Jiajie Song, Xiulong Feng, Yiwei Chen, Waqar Ali Memon, Yuping Shen and 20 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Advancements in Functional Polymeric Scaffolds for Scar-Free Skin Regeneration.Polymer science & technology (Washington, D.C.) · 2026
    Review
  2. A CD14-Targeting In Situ Hydrogel Directs Macrophage Reprogramming to Minimize Scar Formation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Ionic-Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  10. Review
  11. Review
  12. Electric-based dressing for wound management.Frontiers in cellular and infection microbiology · 2026
    Review
  13. Review
  14. Review
  15. Topology in Biological Piezoelectric Materials.Advanced materials (Deerfield Beach, Fla.) · 2025
    Review
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Mujie LiuFunctional and Molecular Imaging Key Lab of Shaanxi Province, Department of Radiology, Tangdu Hospital, Air Force Medical University, Xi'an, 710032, China.
Yuheng WangFunctional and Molecular Imaging Key Lab of Shaanxi Province, Department of Radiology, Tangdu Hospital, Air Force Medical University, Xi'an, 710032, China.ORCID https://orcid.org/0000-0001-6394-1455
Haodong WangHealth Science Center, Ningbo University, Ningbo, 315211, China.
Lihong QiDepartment of Geriatric Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China.
Yuxuan ShangFunctional and Molecular Imaging Key Lab of Shaanxi Province, Department of Radiology, Tangdu Hospital, Air Force Medical University, Xi'an, 710032, China.
Jiajie SongFunctional and Molecular Imaging Key Lab of Shaanxi Province, Department of Radiology, Tangdu Hospital, Air Force Medical University, Xi'an, 710032, China.
Xiulong FengFunctional and Molecular Imaging Key Lab of Shaanxi Province, Department of Radiology, Tangdu Hospital, Air Force Medical University, Xi'an, 710032, China.
Yiwei ChenDepartment of Orthopedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China.
Waqar Ali MemonShenzhen Grubbs Institute and Department of Chemistry, Southern University of Science and Technology, Shenzhen, 518055, China.
Yuping ShenThe Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310000, China.
Xiaodong WuDepartment of Anesthesiology, the First Medical Center of Chinese PLA General Hospital, Beijing, 100853, China.
Jiangbei CaoDepartment of Anesthesiology, the First Medical Center of Chinese PLA General Hospital, Beijing, 100853, China.ORCID https://orcid.org/0000-0003-1218-4639
Yifan ZhaoState Key Laboratory for Manufacturing Systems Engineering, International Joint Laboratory for Micro/Nano Manufacturing and Measurement Technologies, School of Instrument Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, China.ORCID https://orcid.org/0000-0001-5634-5348
Zhuangde JiangState Key Laboratory for Manufacturing Systems Engineering, International Joint Laboratory for Micro/Nano Manufacturing and Measurement Technologies, School of Instrument Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, China.
Dingxin LiuState Key Laboratory of Electrical Insulation and Power Equipment, Centre for Plasma Biomedicine, School of Electrical Engineering, Xi'an Jiaotong University, Xi'an, 710049, China.ORCID https://orcid.org/0000-0003-0910-2903
Shareen ShafiqueState Key Laboratory for Manufacturing Systems Engineering, International Joint Laboratory for Micro/Nano Manufacturing and Measurement Technologies, School of Instrument Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, China.
Shengtao LiState Key Laboratory of Electrical Insulation and Power Equipment, Centre for Plasma Biomedicine, School of Electrical Engineering, Xi'an Jiaotong University, Xi'an, 710049, China.
Guanghao LuState Key Laboratory of Electrical Insulation and Power Equipment, Centre for Plasma Biomedicine, School of Electrical Engineering, Xi'an Jiaotong University, Xi'an, 710049, China.ORCID https://orcid.org/0000-0001-7829-7308
Zhixiang WeiCAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology, Beijing, 100190, China.
Zhijie LiuState Key Laboratory of Electrical Insulation and Power Equipment, Centre for Plasma Biomedicine, School of Electrical Engineering, Xi'an Jiaotong University, Xi'an, 710049, China.
Kun ZhouSchool of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen), Guangdong, 518172, China.
Yuping QuanDepartment of Plastic Surgery and Regenerative Medicine, Fujian Medical University Union Hospital, Fuzhou, 350001, China.
Xiaoyu ZhangDepartment of Medical Engineering, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Xin ZouDepartment of Medical Engineering, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Xuefeng WangFunctional and Molecular Imaging Key Lab of Shaanxi Province, Department of Radiology, Tangdu Hospital, Air Force Medical University, Xi'an, 710032, China.
Na LiuFunctional and Molecular Imaging Key Lab of Shaanxi Province, Department of Radiology, Tangdu Hospital, Air Force Medical University, Xi'an, 710032, China.
Yaqing ZhangDepartment of Pediatric Orthopaedics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, 200092, China.ORCID https://orcid.org/0000-0003-1380-5855
Yiwei HuDepartment of Orthopedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China.ORCID https://orcid.org/0000-0001-6899-3545
Chao HanThe Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310000, China.
Wen WangFunctional and Molecular Imaging Key Lab of Shaanxi Province, Department of Radiology, Tangdu Hospital, Air Force Medical University, Xi'an, 710032, China.

Funding

Collaborative Innovation Center for Modern Science and Technology and Industrial Development of Jiangxi Traditional Medicine 2024ZL487Hovering Program of the Fourth Military Medical University grant no. axjhww to WWMedical Science and Technology Project of Zhejiang Province 2023RC044National Natural Science Foundation of China grant no. 82271213Natural Science Foundation of Beijing grant no. L222100Scientific Research Project of Zhejiang Chinese Medical University grant no.2022JKJNTZ34Young Medical Key Talents Foundation of Jiangsu Province 2018BJ003
6 · The paper itself

Abstract

In this study, an electret-inspired, charge-injected hydrogel called QOSP hydrogel (QCS/OD/SDI/PANI/PS/Plasma) that promotes scar-free healing of bacteria-infected burns through bioelectrical stimulation and immune modulation, is presented. The hydrogel, composed of quaternized chitosan (QCS), oxidized dextran (OD), sulfadiazine (SDI), polystyrene (PS), and polyaniline nanowires (PANI), forms a conductive network capable of storing and releasing electric charges, emulating an electret-like mechanism. This structure delivers bioelectrical signals continuously, enhancing wound healing by regulating immune responses and minimizing fibrosis. In a mouse model of second-degree burns infected with Staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA), the hydrogel accelerates wound healing by 32% and reduces bacterial load by 60%, significantly inhibited scar formation by 40% compared to controls. QOSP hydrogel modulates the Th1/Th2 immune balance toward a Th1-dominant antifibrotic state through quaternized chitosan, thereby reducing collagen deposition by 35%. Electro-dielectric characterization reveals a dielectric constant of 6.2, a 34% improvement in conductivity (3.33 × 10

Indexed as

BurnsHydrogelsWound HealingAnimalsChitosanCicatrixDisease Models, AnimalMicePseudomonas aeruginosaStaphylococcal InfectionsStaphylococcus aureusChitosanHydrogelsbacterially infected burnsbioelectrical stimulationcharge‐injected hydrogelelectretsfibrosis inhibitionimmune modulationscar‐free healing

Identifiers

PMID39951351
PMCPMC11967837

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.