Evidence map›Paper›PMID 39951286›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Advanced Microarrays as Heterogeneous Force-Remodeling Coordinator to Orchestrate Nuclear Configuration and Force-Sensing Mechanotransduction in Stem Cells.

Nana Wang, Yan Hou, Lili Lin, Shihui Xu, Kyubae Lee, Yingjun Yang, Yazhou Chen, Yachun Li, Xiuhui Wang, Yongtao Wang and 1 more

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nana WangDepartment of Orthopedic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Yan HouSchool of Medicine, Shanghai University, Shanghai, 200444, China.
Lili LinDepartment of Pediatrics, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, 200080, China.
Shihui XuSchool of Medicine, Shanghai University, Shanghai, 200444, China.
Kyubae LeeDepartment of Biomedical Materials, Konyang University, Daejeon, 35365, Republic of Korea.
Yingjun YangMaterials Institute of Atomic and Molecular Science, Shaanxi University of Science and Technology, Xi'an, 710021, China.
Yazhou ChenHenan Institute of Advanced Technology, Zhengzhou University, Zhengzhou, 450003, China.
Yachun LiDepartment of Pediatrics, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, 200080, China.
Xiuhui WangInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Yongtao WangSchool of Medicine, Shanghai University, Shanghai, 200444, China.ORCID https://orcid.org/0000-0001-5148-9393
Tao ChenDepartment of Orthopedic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.

Funding

Medicine-Engineering Cross Research Foundation of Shanghai Jiaotong University YG2024QNA33National Natural Science Foundation of China 82302401Science and Technology Research Project of Songjiang District 2024SJKJGG064Shanghai Overseas High-Level Talent Project and High-End Foreign Experts Introduction Plan of Ministry of Science and Technology G2023013020L
6 · The paper itself

Abstract

Integrin and focal adhesion can regulate cytoskeleton distribution to govern actin-related force remodeling and play an important role in nuclear configuration and force-sensing mechanotransduction of stem cells. However, further exploration of the interaction between actinin complex and myosin, kinetics, and molecular mechanism of cytoskeleton structures to nucleate within the engineered stem cells is vague. An extensive comprehension of cell morphogenesis, force remodeling, and nuclear force-sensing mechanotransduction is essential to reveal the basic physical principles of cytoskeleton polymerization and force-related signaling delivery. Advanced microarrays are designed to determine heterogeneous cell morphology and cell adhesion behaviors in stem cells. The heterogeneity from the engineered microarrays is transferred into nuclei to regulate nuclear configuration and force-sensing mechanotransduction by the evaluation of Lamins, YAP, and BrdU expression. Tuning the activation of adhesion proteins and cytoskeleton nucleators to adjust heterogeneous cell mechanics may be the underlying mechanism to change nuclear force-sensing configuration in response to its physiological mechanotransduction in microarrayed stem cells.

Indexed as

Cell NucleusMechanotransduction, CellularStem CellsAnimalsCell AdhesionCytoskeletonHumansadvanced microarraysforce‐sensing mechanotransductionheterogeneous focal adhesionmechanical remodelingnuclear configuration

Identifiers

PMID39951286
PMCPMC11984837

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.