ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Essential Role of the Anterior Piriform Cortex in Mediating Social Novelty Output via a Top-Down Circuit.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Article
- An olfactory-prefrontal cortical circuit supports social recognition.Research square · 2026Article
- Shared and divergent alteration of whole-brain connectivity and sensory deficits in multiple autism mouse models.Molecular psychiatry · 2026Article
- Essential Role of the Anterior Piriform Cortex in Mediating Social Novelty Output via a Top-Down Circuit.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Social novelty is indispensable for a wide range of social behaviors. The medial prefrontal cortex (mPFC), along with other social information hubs, composes the foundational circuitry of social novelty. However, the precise circuit mechanisms that govern social novelty processing remain elusive. The piriform cortex, as the largest olfactory cortex, receives extensive innervation from top-down centers that dictate social behavior. Here, it is shown that the anterior piriform cortex (APC) exhibited an increase in gamma event incidence during social engagement in male mice. In vivo electrophysiology and fiber photometry reveal that APC pyramidal neurons respond more intensely to novel mice than familiar ones. Intriguingly, silencing APC neurons selectively impairs social novelty processing, yet leaves the basic olfactory discrimination capabilities intact. Moreover, the APC inherits social cues from the mPFC and sends feedback projections to the olfactory bulb (OB) to modulate social novelty. These findings unveil the APC's role as extending well beyond olfaction, encompassing a specialized function in social novelty recognition in male mice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.