Evidence map›Paper›PMID 39951245›Full record

ArticleJapanese journal of radiology2025

Age-related changes in the radiologic findings of lobular endocervical glandular hyperplasia: a multicenter study.

Ayumi Ohya, Takuya Fukuzawa, Yuki Himoto, Aki Kido, Takahiro Tsuboyama, Nao Kikkawa, Hideyuki Fukui, Yuko Iraha, Kimiteru Ito, Yasunari Fujinaga

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Japanese journal of radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Lobular Endocervical Glandular Hyperplasia and Related Glandular Disorders: Current Status of Diagnosis with MR Imaging.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ayumi OhyaDepartment of Radiology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan. ayumiayu@shinshu-u.ac.jp.ORCID http://orcid.org/0000-0003-0786-7531
Takuya FukuzawaDepartment of Radiology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan.
Yuki HimotoDepartment of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Aki KidoDepartment of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Takahiro TsuboyamaDepartment of Radiology, Osaka University Graduate School of Medicine, Osaka, Japan.
Nao KikkawaDepartmant of Diagnostic Radiology, National Cancer Center Hospital, Tokyo, Japan.
Hideyuki FukuiDepartment of Radiology, Osaka University Graduate School of Medicine, Osaka, Japan.
Yuko IrahaDepartment of Radiology, Graduate School of Medical Science, University of the Ryukyus, Ginowan, Japan.
Kimiteru ItoDepartmant of Diagnostic Radiology, National Cancer Center Hospital, Tokyo, Japan.
Yasunari FujinagaDepartment of Radiology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the age-related changes in magnetic resonance imaging (MRI) findings of lobular endocervical glandular hyperplasia (LEGH) during long-term follow-up. MATERIALS AND

methodsThis multicenter study included 91 patients who underwent preoperative MRI and had a histopathological diagnosis of LEGH, atypical LEGH, or adenocarcinoma in situ (AIS) with LEGH after surgical resection. Thirty patients underwent follow-up MRIs at intervals of more than 3 months. According to the age and menopausal status, patients were categorized into four groups: group A, 31-40 years; group B, 41-50 years (premenopausal); group C, more than 50 years (premenopausal); group D, postmenopausal. Differences in the MRI findings (size and morphological pattern) were compared among the four groups.

resultsThe lesion volume was the largest in group C and smallest in group D, showing a statistically significant difference (p < 0.05). The typical cosmos pattern was seen in 60.0% of group A, 62.2% of group B, 75.0% of group C, and 29.2% of group D. The cosmos pattern was significantly less frequent in postmenopausal patients compared to premenopausal patients (p < 0.05). During follow-up, five of 12 individuals in group A exhibited the typical cosmos pattern. Among the seven individuals who did not initially show the cosmos pattern, two later developed the typical cosmos pattern. No changes in the lesion pattern were observed in participants in their 40 s up to the premenopausal 50 s. From the premenopausal 50 s to the postmenopausal period, the cosmos pattern changed to a microcystic pattern in one case of atypical LEGH.

conclusionsLEGH increases in volume with age until menopause, along with an increasing frequency of the typical cosmos pattern in MRI. However, after menopause, both the volume of the lesion and frequency of the typical cosmos pattern decrease.

Indexed as

Cervix UteriMagnetic Resonance ImagingUterine Cervical NeoplasmsAdultAgedAge FactorsFemaleFollow-Up StudiesHumansHyperplasiaMiddle AgedRetrospective StudiesCervix uteriCosmos patternLobular endocervical glandular hyperplasiaMagnetic resonance imaging

Identifiers

PMID39951245
PMCPMC12125083

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.