Evidence map›Paper›PMID 39951228›Full record

ArticleBulletin of experimental biology and medicine2025

Microfluidic Chip for Studying the Mechanisms of Allogeneic Progenitor Neuronal Cells Integration into a Mature Neural Network In Vitro.

A A Gladkov, M S Zemlyanskov, Y I Pigareva, V N Kolpakov, V B Kazantsev, I V Mukhina, A S Pimashkin

Abstract read
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Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

A A GladkovNational Research Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia.
M S ZemlyanskovNational Research Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia.
Y I PigarevaNational Research Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia.
V N KolpakovNational Research Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia.
V B KazantsevNational Research Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia.
I V MukhinaNational Research Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia.
A S PimashkinNational Research Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia. pimashkin@neuro.nnov.ru.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The formation of functional connections between cells derived from neuronal progenitor cells (NPCs) and the developed neuronal network is a crucial task in neurobiology and cellular technologies for medical applications. We developed a technique to co-culture NPCs and mature neuronal cells in a three-chamber microfluidic chip in vitro and studied the features of functional connections among cells derived from NPCs during their integration into a network of differentiated neurons. Starting from day 20 of primary culture development, a network forms from integrated NPCs, which ensures the distribution of bioelectrical activity among neurons in a manner similar to that of differentiated cells.

Indexed as

Lab-On-A-Chip DevicesMicrofluidic Analytical TechniquesNerve NetNeural Stem CellsNeuronsAnimalsCell DifferentiationCells, CulturedCoculture TechniquesMiceRatsmicroelectrode arraysmicrofluidic chipsneural progenitor cellsPDMSprimary cultures of cerebral cortex neurons

Identifiers

PMID39951228

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.