Evidence map›Paper›PMID 39951227›Full record

ArticleBulletin of experimental biology and medicine2025

Subpopulation Alterations of Vascular Endothelial Cells in the Cerebral Cortex in Experimental Models of Alzheimer's Disease.

T I Baranich, A S Averchuk, M V Kukla, N A Rozanova, A V Stavrovskaya, V V Glinkina, V S Sukhorukov, A B Salmina

Abstract read
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Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

T I BaranichResearch Center of Neurology, Moscow, Russia. baranich_tatyana@mail.ru.
A S AverchukResearch Center of Neurology, Moscow, Russia.
M V KuklaResearch Center of Neurology, Moscow, Russia.
N A RozanovaResearch Center of Neurology, Moscow, Russia.
A V StavrovskayaResearch Center of Neurology, Moscow, Russia.
V V GlinkinaPirogov Russian National Research Medical University, Moscow, Russia.
V S SukhorukovResearch Center of Neurology, Moscow, Russia.
A B SalminaResearch Center of Neurology, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Angiogenesis is regulated by various types of endothelial cells: tip cells, stalk cells, and phalanx cells. In this study, the changes in cerebral angiogenesis and the characteristics of angiogenesis in the prefrontal cortex of Alzheimer's disease (AD) mice were investigated. AD was induced by injection of β-amyloid into the hippocampus. The animals underwent cognitive testing, and their brains were analyzed using immunohistochemical techniques to evaluate angiogenesis. The results showed an increase in the proliferation of endothelial cells and altered ratio of tip, stalk, and phalanx cells. Vascular branching and density in the prefrontal cortex were decreased, indicating an unproductive form of angiogenesis in AD. Obtained results highlight the link between changes in angiogenesis and cognitive decline, confirming the importance of vascular dysfunction in AD progression.

Indexed as

Alzheimer DiseaseCerebral CortexEndothelial CellsNeovascularization, PathologicPrefrontal CortexAmyloid beta-PeptidesAnimalsCell ProliferationDisease Models, AnimalHippocampusMaleMiceAmyloid beta-PeptidesAlzheimer’s diseaseangiogenesiscognitive functionsendotheliumprefrontal cortex

Identifiers

PMID39951227

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.