Evidence map›Paper›PMID 39951220›Full record

ArticleAnnals of nuclear medicine2025

Comparison of the diagnostic accuracy of VSBONE BSI versions for detecting bone metastases in breast and prostate carcinoma patients using conventional and CZT detector gamma cameras.

Akiko Oya, Michihiro Nakayama, Takahiro Uno, Haruka Ueda, Ippei Yoshida, Atsushi Fujiya, Yurina Nomura, Atsutaka Okizaki

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Annals of nuclear medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Akiko OyaDepartment of Radiology, Asahikawa Medical University, Midorigaoka-Higashi 2-1-1-1, Asahikawa, Hokkaido, 078-8510, Japan.
Michihiro NakayamaDepartment of Radiology, Asahikawa Medical University, Midorigaoka-Higashi 2-1-1-1, Asahikawa, Hokkaido, 078-8510, Japan.
Takahiro UnoDivision of Radiology, Asahikawa Medical University Hospital, Midorigaoka-Higashi 2-1-1-1, Asahikawa, Hokkaido, 078-8510, Japan.
Haruka UedaDepartment of Radiology, Asahikawa Medical University, Midorigaoka-Higashi 2-1-1-1, Asahikawa, Hokkaido, 078-8510, Japan.
Ippei YoshidaDepartment of Radiology, Asahikawa Medical University, Midorigaoka-Higashi 2-1-1-1, Asahikawa, Hokkaido, 078-8510, Japan.
Atsushi FujiyaDepartment of Radiology, Asahikawa Medical University, Midorigaoka-Higashi 2-1-1-1, Asahikawa, Hokkaido, 078-8510, Japan.
Yurina NomuraDepartment of Radiology, Asahikawa Medical University, Midorigaoka-Higashi 2-1-1-1, Asahikawa, Hokkaido, 078-8510, Japan.
Atsutaka OkizakiDepartment of Radiology, Asahikawa Medical University, Midorigaoka-Higashi 2-1-1-1, Asahikawa, Hokkaido, 078-8510, Japan. okizaki@asahikawa-med.ac.jp.ORCID http://orcid.org/0000-0001-8203-827X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveBone scintigraphy is widely employed for detecting bone metastases, with the bone scan index (BSI) gaining traction as a quantitative tool in this domain. VSBONE BSI, an automated image analysis software, identifies abnormal hyperaccumulation areas in bone scintigraphy and computes BSI scores. The software, originally developed using data from conventional gamma cameras (C-Camera), has undergone two upgrades. This study hypothesized that the upgrades enhance the diagnostic accuracy for bone metastases and assessed the software's applicability to images obtained using a cadmium-zinc-telluride detector gamma camera (CZT-Camera). The aim was to compare the diagnostic accuracy of VSBONE BSI across software versions using both conventional and CZT detectors and to evaluate its utility.

methodsA total of 287 patients with breast or prostate carcinoma who underwent whole-body bone scintigraphy were included. VSBONE BSI automatically analyzed and calculated the BSI. The analysis results were compared with the presence or absence of metastases for each software version by using detector type of camera. The diagnostic agreement was evaluated.

resultsReceiver operating characteristic analysis showed an area under the curve (AUC) exceeding 0.7 across all groups, indicating good diagnostic performance. AUC values significantly increased with version upgrades for all patients and for breast carcinoma patients. In metastasis-negative cases, BSI values decreased with each software version upgrade, with the reduction being more pronounced in breast carcinoma patients scanned with the CZT-Camera.

conclusionsUsing the VSBONE BSI, version 2 or 3 had a higher rate of diagnostic concordance with the clinical prognosis than version 1. In metastasis-negative patients, newer software versions yielded lower BSI values, especially for breast carcinoma patients scanned using the CZT-Camera, highlighting the improved diagnostic accuracy of the updated software.

Indexed as

Bone NeoplasmsBreast NeoplasmsCadmiumGamma CamerasProstatic NeoplasmsRadionuclide ImagingTelluriumZincAdultAgedAged, 80 and overFemaleHumansImage Processing, Computer-AssistedMaleMiddle AgedCadmiumCdZnTeTelluriumZincBone metastasisBone scintigraphyCadmium–zinc–telluride (CZT)Deep learningSemiconductor detector

Identifiers

PMID39951220

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.