Evidence map›Paper›PMID 39951177›Full record

ArticleGeroScience2025

Test of Rapamycin in Aging Dogs (TRIAD): study design and rationale for a prospective, parallel-group, double-masked, randomized, placebo-controlled, multicenter trial of rapamycin in healthy middle-aged dogs from the Dog Aging Project.

Amanda E Coleman, Kate E Creevy, Rozalyn Anderson, May J Reed, Virginia R Fajt, Kathleen M Aicher, Genna Atiee, Brian G Barnett, Ryan D Baumwart, Beth Boudreau and 42 more

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Dogs and humans share biomarkers of mortality.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
    Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

52 authors.

Amanda E Coleman *Department of Small Animal Medicine and Surgery, University of Georgia, Athens, GA, USA. mericksn@uga.edu.ORCID 0000-0001-5476-5963
Kate E Creevy *Department of Small Animal Clinical Sciences, Texas A&M University, College Station, TX, USA.
Rozalyn AndersonDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, USA.
May J ReedDepartment of Medicine, University of Washington, Seattle, WA, USA.
Virginia R FajtDepartment of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX, USA.
Kathleen M AicherDepartment of Small Animal Clinical Sciences, Texas A&M University, College Station, TX, USA.
Genna AtieeDepartment of Small Animal Clinical Sciences, Texas A&M University, College Station, TX, USA.
Brian G BarnettDepartment of Small Animal Clinical Sciences, Texas A&M University, College Station, TX, USA.
Ryan D BaumwartDepartment of Veterinary Clinical Sciences, Washington State University, Pullman, WA, USA.
Beth BoudreauDepartment of Small Animal Clinical Sciences, Texas A&M University, College Station, TX, USA.
Suzanne M CunninghamDepartment of Clinical Sciences, Tufts University, North Grafton, MA, USA.
Matthew D DunbarCenter for Studies in Demography and Ecology, University of Washington, Seattle, WA, USA.
Bobbie DitzlerDepartment of Small Animal Clinical Sciences, Texas A&M University, College Station, TX, USA.
Anna M FergusonDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
Kiersten K ForsythDepartment of Small Animal Clinical Sciences, Texas A&M University, College Station, TX, USA.
Anya N GambinoDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
Sonya G GordonDepartment of Small Animal Clinical Sciences, Texas A&M University, College Station, TX, USA.
Hillary K HammondDepartment of Small Animal Medicine and Surgery, University of Georgia, Athens, GA, USA.
Sydney N HollandDepartment of Small Animal Clinical Sciences, Texas A&M University, College Station, TX, USA.
Mary K IannacconeDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
Kate IllingDepartment of Small Animal Clinical Sciences, Texas A&M University, College Station, TX, USA.
Saki KadotaniDepartment of Veterinary Clinical Medicine, University of Illinois, Urbana, IL, USA.
Shelby A KnowlesDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
Evan L MacLeanCollege of Veterinary Medicine, University of Arizona, Tucson, AZ, USA.
Brian A MaranOlympic Veterinary Cardiology, Everett, WA, USA.
Lauren E MarkovicDepartment of Small Animal Medicine and Surgery, University of Georgia, Athens, GA, USA.
Stephanie McGrathDepartment of Clinical Sciences, Colorado State University, Fort Collins, CO, USA.
Rachel L MelvinDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
Mikaela S MuellerOlympic Veterinary Cardiology, Everett, WA, USA.
O Lynne NelsonDepartment of Veterinary Clinical Sciences, Washington State University, Pullman, WA, USA.
Natasha J OlbyDepartment of Clinical Sciences, North Carolina State University, Raleigh, NC, USA.
Theresa E PancottoSpecialists in Companion Animal Neurology, Naples, FL, USA.
Elizabeth ParsleyDepartment of Clinical Sciences, Tufts University, North Grafton, MA, USA.
Brianna M PotterDepartment of Clinical Sciences, Colorado State University, Fort Collins, CO, USA.
Jena O PrescottDepartment of Small Animal Clinical Sciences, Texas A&M University, College Station, TX, USA.
Ashley B SaundersDepartment of Small Animal Clinical Sciences, Texas A&M University, College Station, TX, USA.
Holly M SawyerOlympic Veterinary Cardiology, Everett, WA, USA.
Brian A ScansenDepartment of Clinical Sciences, Colorado State University, Fort Collins, CO, USA.
Sarah M SchmidDepartment of Small Animal Clinical Sciences, Texas A&M University, College Station, TX, USA.
Courtney C SmithChesapeake Veterinary Cardiology Associates, Lawndale, CA, USA.
Sonja S TjostheimDepartment of Medical Sciences, University of Wisconsin, Madison, WI, USA.
M Katherine TolbertDepartment of Small Animal Clinical Sciences, Texas A&M University, College Station, TX, USA.
Melissa A TropfDepartment of Veterinary Clinical Sciences, Iowa State University, Ames, IA, USA.
Lance C VisserDepartment of Clinical Sciences, Colorado State University, Fort Collins, CO, USA.
Jessica L WardDepartment of Veterinary Clinical Sciences, Iowa State University, Ames, IA, USA.
Sonya R WesselowskiDepartment of Small Animal Clinical Sciences, Texas A&M University, College Station, TX, USA.
Rebecca C WindsorWheat Ridge Animal Hospital, Wheat Ridge, CO, USA.
Vicky K YangDepartment of Clinical Sciences, Tufts University, North Grafton, MA, USA.
Audrey RupleDepartment of Population and Health Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
Daniel E L PromislowJean Mayer USDA Human Nutrition Research Center On Aging, Tufts University, Boston, MA, USA.
Matt KaeberleinDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
Dog Aging Project Consortium

Funding

The Dog Aging Project: Genetic and Environmental Determinants of Healthy Aging in Companion Dogs Competitive RevisionU19AG057377 · NIA · UNIVERSITY OF WASHINGTON · PI PROMISLOW, DANIEL EDWARD · 2018 to 2023
$29.0M
Test of Rapamycin in Aging Dogs (TRIAD)R01AG090843 · NIA · TEXAS A&M AGRILIFE RESEARCH · PI Rozalyn M. Anderson, Kate Elizabeth Creevy · 2025 to 2026
$4.7M
NIA NIH HHS R01 AG090843NIA NIH HHS U19 AG057377NIA NIH HHS UI9AG057377
6 · The paper itself

Abstract

Companion dogs are a powerful model for aging research given their morphologic and genetic variability, risk for age-related disease, and habitation of the human environment. In addition, the shorter life expectancy of dogs compared to human beings provides a unique opportunity for an accelerated timeline to test interventions that might extend healthy lifespan. The Test of Rapamycin In Aging Dogs (TRIAD) randomized clinical trial is a parallel-group, double-masked, randomized, placebo-controlled, multicenter trial that will test the ability of rapamycin to prolong lifespan and improve several healthspan metrics in healthy, middle-aged dogs recruited from Dog Aging Project participants. Here, we describe the rationale, design, and goals of the TRIAD randomized clinical trial, the first rigorous test of a pharmacologic intervention against biological aging with lifespan and healthspan metrics as endpoints to be performed outside of the laboratory in any species.

Indexed as

AgingLongevitySirolimusAnimalsClinical Trials, Veterinary as TopicDogsDouble-Blind MethodFemaleMaleMulticenter Studies as TopicProspective StudiesSirolimusCanineHealthspanLife spanLifespanLongevityRapamycin

Identifiers

PMID39951177
PMCPMC12181551

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.