Evidence map›Paper›PMID 39951012›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Multi-Omics Analysis Reveals Impacts of LincRNA Deletion on Yeast Protein Synthesis.

Ling Qin, Yuyang Pan, Songlyu Xue, Zhibo Yan, Chufan Xiao, Xiufang Liu, Dan Yuan, Jin Hou, Mingtao Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Truncation ofSynthetic and systems biotechnology · 2026
    Article
  2. Review
  3. Multi-Omics Analysis Reveals Impacts of LincRNA Deletion on Yeast Protein Synthesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ling QinSchool of Food Science and Engineering, South China University of Technology, Guangzhou, 510641, China.
Yuyang PanSchool of Food Science and Engineering, South China University of Technology, Guangzhou, 510641, China.
Songlyu XueSchool of Food Science and Engineering, South China University of Technology, Guangzhou, 510641, China.
Zhibo YanSchool of Food Science and Engineering, South China University of Technology, Guangzhou, 510641, China.
Chufan XiaoSchool of Food Science and Engineering, South China University of Technology, Guangzhou, 510641, China.
Xiufang LiuSchool of Food Science and Engineering, South China University of Technology, Guangzhou, 510641, China.
Dan YuanSchool of Food Science and Engineering, South China University of Technology, Guangzhou, 510641, China.
Jin HouState Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, China.
Mingtao HuangSchool of Food Science and Engineering, South China University of Technology, Guangzhou, 510641, China.ORCID https://orcid.org/0000-0003-2359-1010

Funding

Fundamental Research Funds for the Central Universities 2024ZYGXZR015National Key Research and Development Program of China 2021YFC2100500Science and Technology Program of Guangzhou 2024A04J3562
6 · The paper itself

Abstract

Non-coding RNAs (ncRNAs) are widespread across various genomic regions and play a crucial role in modulating gene expression and cellular functions, thereby increasing biological complexity. However, the relationship between ncRNAs and the production of heterologous recombinant proteins (HRPs) remains elusive. Here, a yeast library is constructed by deleting long intergenic ncRNAs (lincRNAs), and 21 lincRNAs that affect α-amylase secretion are identified. Targeted deletions of SUT067, SUT433, and CUT782 are found to be particularly effective. Transcriptomic and metabolomic analyses of the top three strains indicate improvements in energy metabolism and cytoplasmic translation, which enhances ATP supply and protein synthesis. Moreover, a yeast strain, derived from the SUT433 deletion, that can secrete ≈4.1 g L⁻

Indexed as

Protein BiosynthesisRNA, Long NoncodingSaccharomyces cerevisiaeSaccharomyces cerevisiae Proteinsalpha-AmylasesGene Expression Regulation, FungalMultiomicsRecombinant Proteinsalpha-AmylasesRecombinant ProteinsRNA, Long NoncodingSaccharomyces cerevisiae ProteinslincRNAsmetabolic engineeringprotein secretionrapid growthribosomal proteins (RPs)

Identifiers

PMID39951012
PMCPMC11967807

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.