Evidence map›Paper›PMID 39950970›Full record

ReviewEndocrinology2025

Integral Roles of the TGFβ Signaling Pathway in Uterine Function and Disease.

Anna Catherine Unser, Diana Monsivais

Abstract readReview
In one paragraph

Review in Endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Anna Catherine UnserDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0009-0001-4678-1469
Diana MonsivaisDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0001-5660-6392

Funding

Targeting the endometrial stem cell niche inendometriosisR01HD105800 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Diana Monsivais · 2022 to 2026
$2.5M
Burroughs Wellcome FundEunice Kennedy Shriver National Institute of Child Health and Human Development R01-HD105800Next Gen Pregnancy NGP10125NICHD NIH HHS R01 HD105800
6 · The paper itself

Abstract

The uterus is a complex organ that requires precise signaling networks to mediate functions necessary for homeostasis and reproductive processes. The transforming growth factor β (TGFβ) superfamily regulates integral signaling pathways throughout many physiological processes, including cell proliferation, differentiation, and development. In this review, we summarize the current understanding of how the TGFβ signaling family controls key uterine functions, with a specific focus on the endometrium. These uterine functions include endometrial receptivity, implantation, decidualization, placentation, remodeling, and regeneration. Improving our understanding of the signaling networks that regulate these processes is integral to identifying, diagnosing, and treating uterine and reproductive diseases such as endometriosis, adenomyosis, recurrent pregnancy loss, and recurrent implantation failure.

Indexed as

Signal TransductionTransforming Growth Factor betaUterine DiseasesUterusAnimalsEmbryo ImplantationEndometriumFemaleHumansPregnancyTransforming Growth Factor betaendometriosisendometriumTGFβ signalinguterine diseaseuterus

Identifiers

PMID39950970
PMCPMC11843549

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.