ArticleACS infectious diseases2025
Expanding the Landscape of Dual Action Antifolate Antibacterials through 2,4-Diamino-1,6-dihydro-1,3,5-triazines.
Abstract read
In one paragraph
Article in ACS infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- A bibliometric review of triazine hybrids: synthesis, reactions, and applications spanning the last quarter-century (2000-2025).RSC advances · 2025Review
- Sonosynthesis of new functionalized optically active triazinesRSC advances · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
John D GeorgiadesDepartment of Chemistry, Washington University in St. Louis, One Brookings Drive, St. Louis, Missouri 63130, United States.ORCID 0009-0008-4783-1553
Daniel A BerkovichDepartment of Biology, Washington University in St Louis, One Brookings Drive, St Louis, Missouri 63130, United States.ORCID 0000-0002-4890-5971
Samuel R McKeeDepartment of Molecular Microbiology, Center for Women's Infectious Disease Research, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, Missouri 63110, United States.
Angela R SmithDepartment of Chemistry, Washington University in St. Louis, One Brookings Drive, St. Louis, Missouri 63130, United States.
Banumathi SankaranMolecular Biophysics and Integrated Imaging, The Berkeley Center for Structural Biology, Advanced Light Source, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, California 94720, United States.
Kelly N FlentieDepartment of Molecular Microbiology, Center for Women's Infectious Disease Research, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, Missouri 63110, United States.
Carlos H CastañedaDepartment of Chemistry and Physics, Southeast Missouri State University, One University Plaza, Cape Girardeau, Missouri 63701, United States.
Daniel G GrohmannDepartment of Chemistry and Physics, Southeast Missouri State University, One University Plaza, Cape Girardeau, Missouri 63701, United States.
Ram RohatgiDepartment of Chemistry and Physics, Southeast Missouri State University, One University Plaza, Cape Girardeau, Missouri 63701, United States.
Carrie LaskyDepartment of Chemistry and Physics, Southeast Missouri State University, One University Plaza, Cape Girardeau, Missouri 63701, United States.
Twila A MasonDepartment of Biology, Southeast Missouri State University, One University Plaza, Cape Girardeau, Missouri 63701, United States.
James E ChampineDepartment of Biology, Southeast Missouri State University, One University Plaza, Cape Girardeau, Missouri 63701, United States.
Patricia A MillerDepartment of Chemistry and Biochemistry, University of Notre Dame, 251 Nieuwland Science Hall, Notre Dame, Indiana 46556, United States.
Ute MöllmannLeibniz Institute for Natural Products Research and Infection Biology, Hans Knöll Institute, Beutenbergstrasse 11a, D-07745 Jena, Germany.
Garrett C MoraskiDepartment of Chemistry and Biochemistry, University of Notre Dame, 251 Nieuwland Science Hall, Notre Dame, Indiana 46556, United States.ORCID 0000-0002-6992-5584
Scott G FranzblauInstitute for Tuberculosis Research, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood St., Chicago, Illinois 60612, United States.ORCID 0000-0002-8698-0243
Marvin J MillerDepartment of Chemistry and Biochemistry, University of Notre Dame, 251 Nieuwland Science Hall, Notre Dame, Indiana 46556, United States.ORCID 0000-0002-3704-8214
Christina L StallingsDepartment of Molecular Microbiology, Center for Women's Infectious Disease Research, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, Missouri 63110, United States.
Joseph M JezDepartment of Biology, Washington University in St Louis, One Brookings Drive, St Louis, Missouri 63130, United States.
Bruce A HathawayDepartment of Chemistry and Physics, Southeast Missouri State University, One University Plaza, Cape Girardeau, Missouri 63701, United States.
Timothy A WencewiczDepartment of Chemistry, Washington University in St. Louis, One Brookings Drive, St. Louis, Missouri 63130, United States.ORCID 0000-0002-5839-6672
Funding
User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PAUL David ADAMS, Gregory L Hura · 2017 to 2026
$28.6MDesign, Syntheses and Studies of Novel Antituberculosis AgentsR37AI054193 · NIAID · UNIVERSITY OF NOTRE DAME · PI MILLER, MARVIN J · 2016 to 2025
$5.2MSTRUCTURAL, MECHANISTIC, & EVOLUTIONARY CHARACTERIZATION OF TETRACYCLINE DESTRUCTASESU01AI123394 · NIAID · WASHINGTON UNIVERSITY · PI DANTAS, GAUTAM, WENCEWICZ, TIMOTHY ADAM · 2020 to 2025
$4.1MStructure-based microbially targeted prodrugsR01AI171514 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI DOWD, CYNTHIA SCHIECK, JEZ, JOSEPH MARTIN · 2022 to 2025
$4.0MDesign/Syntheses/Studies/Novel Antituberculosis AgentsR01AI054193 · NIAID · UNIVERSITY OF NOTRE DAME · PI MILLER, MARVIN J · 2004 to 2014
$3.2MNIAID NIH HHS R01 AI054193NIAID NIH HHS R01 AI171514NIAID NIH HHS R37 AI054193NIAID NIH HHS U01 AI123394NIGMS NIH HHS P30 GM124169
Abstract
Antibiotics that operate
Indexed as
Anti-Bacterial AgentsFolic Acid AntagonistsTriazinesCrystallography, X-RayEscherichia coliMicrobial Sensitivity TestsMycobacterium abscessusPseudomonas aeruginosaTetrahydrofolate DehydrogenaseAnti-Bacterial AgentsFolic Acid AntagonistsTetrahydrofolate DehydrogenaseTriazinesantibioticantifolatedihydrofolate reductasedual mechanismmembrane disruptiontriazine
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.