Evidence map›Paper›PMID 39950948›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Intestinal Gastrin/CCKBR Axis Protects against Type 2 Diabetes by Reducing Intestinal Glucose Absorption through the PI3K/Akt/eIF4B Signaling Pathway.

Xue Liu, Xing Liu, Yunpeng Liu, Anxiong Long, Wei Liu, Shiyun Sun, Shuaibing Lu, Xianxian Wu, Xiaodi Jia, Pedro A Jose and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xue LiuInstitute of Laboratory Animal Sciences (CAMS & PUMC), National Center of Technology Innovation for Animal Model, National Human Diseases Animal Model Resource Center, NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, 100021, Beijing, China.
Xing LiuInstitute of Laboratory Animal Sciences (CAMS & PUMC), National Center of Technology Innovation for Animal Model, National Human Diseases Animal Model Resource Center, NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, 100021, Beijing, China.
Yunpeng LiuInstitute of Laboratory Animal Sciences (CAMS & PUMC), National Center of Technology Innovation for Animal Model, National Human Diseases Animal Model Resource Center, NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, 100021, Beijing, China.
Anxiong LongInstitute of Laboratory Animal Sciences (CAMS & PUMC), National Center of Technology Innovation for Animal Model, National Human Diseases Animal Model Resource Center, NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, 100021, Beijing, China.
Wei LiuGraduate School of Hebei North University, Zhangjiakou, Hebei, 075031, China.
Shiyun SunInstitute of Laboratory Animal Sciences (CAMS & PUMC), National Center of Technology Innovation for Animal Model, National Human Diseases Animal Model Resource Center, NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, 100021, Beijing, China.
Shuaibing LuDepartment of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100021, Beijing, China.
Xianxian WuInstitute of Laboratory Animal Sciences (CAMS & PUMC), National Center of Technology Innovation for Animal Model, National Human Diseases Animal Model Resource Center, NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, 100021, Beijing, China.
Xiaodi JiaTaihe County People's Hospital, The Taihe Hospital of Wannan Medical College, 21 Jiankang Road, Taihe County, Anhui Province, 236600, China.
Pedro A JoseDepartment of Pharmacology and Physiology, The George Washington University School of Medicine & Health Sciences, Washington, DC, 20052, USA.
Qiang WeiInstitute of Laboratory Animal Sciences (CAMS & PUMC), National Center of Technology Innovation for Animal Model, National Human Diseases Animal Model Resource Center, NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, 100021, Beijing, China.
Xiaoliang JiangInstitute of Laboratory Animal Sciences (CAMS & PUMC), National Center of Technology Innovation for Animal Model, National Human Diseases Animal Model Resource Center, NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, 100021, Beijing, China.
Haizeng ZhangDepartment of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100021, Beijing, China.
Zhiwei YangInstitute of Laboratory Animal Sciences (CAMS & PUMC), National Center of Technology Innovation for Animal Model, National Human Diseases Animal Model Resource Center, NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, 100021, Beijing, China.ORCID https://orcid.org/0000-0001-6943-004X

Funding

Spatiotemporal transregulation of D1-like angiotensin receptors in genetically...P01HL074940 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI JOSE, PEDRO A. · 2004 to 2020
$31.8M
RENAL DOPAMINE-1 RECEPTOR DEFECT IN HYPERTENSIONR01DK039308 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI JOSE, PEDRO A. · 1987 to 2020
$7.4M
D2 receptor variation and renal dysfunctionR01DK134574 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI Pedro A. Jose · 2023 to 2026
$2.8M
Lipid rafts, dopamine 1 receptor, and hypertensionR01DK119652 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI JOSE, PEDRO A. · 2020 to 2023
$2.6M
Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences 2021-1-I2M-035Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences 2021-I2M-1-010Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences 2021-I2M-1-021Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences 2021-I2M-1-072Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences CAMSNational Key Research and Development Program 2022YFF0710600National Natural Science Foundation (China) 82161138027National Natural Science Foundation (China) 82270289National Natural Science Foundation (China) 82300497NHLBI NIH HHS P01 HL074940NIDDK NIH HHS R01 DK039308NIDDK NIH HHS R01 DK119652NIDDK NIH HHS R01 DK134574NIH HHS P01HL074940NIH HHS R01DK039308NIH HHS R01DK119652NIH HHS R01DK134574 PAJ
6 · The paper itself

Abstract

The Gastrin/CCKBR axis is essential for inhibiting intestinal sodium absorption, but its effects on intestinal glucose metabolism remain elusive. This study aims to determine the role of intestinal Gastrin/CCKBR on glucose absorption in the development of type 2 diabetes (T2D). Intestinal epithelial cell-specific Cckbr knockout mice and control wild-type mice are fed normal diet (ND, 10% fat) or high fat diet (HFD, 60% fat) to study the effect of intestinal Gastrin/CCKBR on blood glucose levels. Gastrin-SiO

Indexed as

Diabetes Mellitus, Type 2GastrinsGlucoseIntestinal AbsorptionReceptor, Cholecystokinin BAnimalsDiet, High-FatHumansMaleMiceMice, Inbred C57BLMice, KnockoutPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionGastrinsGlucosePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktReceptor, Cholecystokinin Bcholecystokinin B receptorGastrin‐SiO2 microspheresglucose transporter type 2sodium/glucose cotransporter 1type 2 diabetes

Identifiers

PMID39950948
PMCPMC11967862

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.